Raposo Alberto, Martínez-Ortiz María José, Buendía Ana, Guillén Elena, Bermúdez Cristina, García-Purriños Francisco
Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Universitario Los Arcos del Mar Menor, San Javier, 30739 Murcia, Spain.
Department of Medical Oncology, Hospital Universitario Santa Lucia, Cartagena, 30202 Murcia, Spain.
Mol Clin Oncol. 2022 Feb;16(2):48. doi: 10.3892/mco.2021.2481. Epub 2021 Dec 23.
Sinonasal small cell carcinoma (SmCC) is a rare type of neoplasm. The current case report describes the case of a 30-year-old male patient with stage IV SmCC who underwent concurrent radiotherapy (RT) plus etoposide-cisplatin treatment. Positron emission tomography (PET)/computed tomography (CT) and fibroscopy examination showed complete remission at 3 months post-treatment. However, leptomeningeal metastasis (LM) occurred at 9 months. A literature search identified no previous case reports describing LM of SmCC. The patient was treated with concurrent RT plus irinotecan-gemcitabine. During the sixth cycle of irinotecan-gemcitabine, the patient required intensive care admission due to severe acute respiratory syndrome-related coronavirus 2-associated pneumonia. Following clearance of the pneumonia, LM was assessed using PET/CT and MRI at 3 months, which revealed a complete response to irinotecan-gemcitabine. In May 2021, the patient succumbed to LM following disease recurrence. The findings of this case report should encourage other authors to publish their treatment outcomes regarding SmCC. More clinical trials are required to achieve better results in terms of patient outcome.
鼻窦小细胞癌（SmCC）是一种罕见的肿瘤类型。本病例报告描述了一名30岁IV期SmCC男性患者，接受了同步放疗（RT）加依托泊苷-顺铂治疗。正电子发射断层扫描（PET）/计算机断层扫描（CT）和纤维镜检查显示治疗后3个月完全缓解。然而，9个月时发生了软脑膜转移（LM）。文献检索未发现先前描述SmCC的LM的病例报告。该患者接受了同步RT加伊立替康-吉西他滨治疗。在伊立替康-吉西他滨的第六个周期中，患者因严重急性呼吸综合征冠状病毒2相关性肺炎需要入住重症监护病房。肺炎清除后，在3个月时使用PET/CT和MRI评估LM，结果显示对伊立替康-吉西他滨完全缓解。2021年5月，患者在疾病复发后死于LM。本病例报告的结果应鼓励其他作者发表他们关于SmCC的治疗结果。需要更多的临床试验以在患者预后方面取得更好的结果。
