Asadi Mohammad Reza, Moslehian Marziyeh Sadat, Sabaie Hani, Poornabi Marziye, Ghasemi Elham, Hassani Mehdi, Hussen Bashdar Mahmud, Taheri Mohammad, Rezazadeh Maryam
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, School of Medicine, Shahroud University of Medical Science, Shahroud, Iran.
Front Oncol. 2021 Dec 24;11:797549. doi: 10.3389/fonc.2021.797549. eCollection 2021.
Stress granule (SG) formation is a well-known cellular mechanism for minimizing stress-related damage and increasing cell survival. In addition to playing a critical role in the stress response, SGs have emerged as critical mediators in human health. It seems logical that SGs play a key role in cancer cell formation, development, and metastasis. Recent studies have shown that many SG components contribute to the anti-cancer medications' responses through tumor-associated signaling pathways and other mechanisms. SG proteins are known for their involvement in the translation process, control of mRNA stability, and capacity to function in both the cytoplasm and nucleus. The current systematic review aimed to include all research on the impact of SGs on the mechanism of action of anti-cancer medications and was conducted using a six-stage methodological framework and the PRISMA guideline. Prior to October 2021, a systematic search of seven databases for eligible articles was performed. Following the review of the publications, the collected data were subjected to quantitative and qualitative analysis. Notably, Bortezomib, Sorafenib, Oxaliplatin, 5-fluorouracil, Cisplatin, and Doxorubicin accounted for the majority of the medications examined in the studies. Overall, this systematic scoping review attempts to demonstrate and give a complete overview of the function of SGs in the mechanism of action of anti-cancer medications by evaluating all research.
应激颗粒（SG）的形成是一种众所周知的细胞机制，可将应激相关损伤降至最低并提高细胞存活率。除了在应激反应中发挥关键作用外，应激颗粒已成为人类健康的关键介质。应激颗粒在癌细胞的形成、发展和转移中发挥关键作用似乎是合乎逻辑的。最近的研究表明，许多应激颗粒成分通过肿瘤相关信号通路和其他机制对抗癌药物的反应有贡献。应激颗粒蛋白以参与翻译过程、控制mRNA稳定性以及在细胞质和细胞核中发挥功能的能力而闻名。本系统综述旨在纳入所有关于应激颗粒对抗癌药物作用机制影响的研究，并使用六阶段方法框架和PRISMA指南进行。在2021年10月之前，对七个数据库进行了系统搜索以查找符合条件的文章。在对出版物进行审查之后，对收集到的数据进行了定量和定性分析。值得注意的是，硼替佐米、索拉非尼、奥沙利铂、5-氟尿嘧啶、顺铂和多柔比星占研究中所检查药物的大部分。总体而言，本系统范围综述试图通过评估所有研究来展示并全面概述应激颗粒在抗癌药物作用机制中的功能。
