McQueenie Ross, Jani Bhautesh Dinesh, Siebert Stefan, McLoone Philip, McCowan Colin, Macdonald Sara, Mair Frances S, Nicholl Barbara I
Institute of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK.
Institute of Infection, Immunity and Inflammation, MVLS, University of Glasgow, Glasgow, UK.
J Multimorb Comorb. 2021 Dec 21;11:26335565211005870. doi: 10.1177/26335565211005870. eCollection 2021 Jan-Dec.
Chronic pain is often experienced alongside other long-term conditions (LTCs), yet our understanding of this, particularly in relation to multimorbidity (≥2 LTCs) is poor. We aimed to examine associations between the presence/extent of chronic pain with type/number of LTCs experienced.
We examined the relationship between number/type of LTCs (N = 45) in UK Biobank participants (n = 500,295) who self-reported chronic pain lasting ≥3 months in seven body sites or widespread. Relative risk ratios (RRR) for presence/extent of chronic pain sites were compared using logistic regression adjusted for sociodemographic (sex/age/socioeconomic status) and lifestyle factors (smoking/alcohol intake/BMI/physical activity).
218,648 participants self-reported chronic pain. Of these, 69.1% reported ≥1 LTC and 36.2% reported ≥2 LTCs. In 31/45 LTCs examined, >50% of participants experienced chronic pain. Chronic pain was common with migraine/headache and irritable bowel syndrome where pain is a primary symptom, but also with mental health conditions and diseases of the digestive system. Participants with >4 LTCs were over three times as likely to have chronic pain (RRR 3.56, 95% confidence intervals (CIs) 3.44-3.68) and 20 times as likely to have widespread chronic pain (RRR 20.13, 95% CI 18.26-22.19) as those with no LTCs.
Chronic pain is extremely common across a wide range of LTCs. People with multimorbidity were at higher risk of having a greater extent of chronic pain. These results show that chronic pain is a key factor for consideration in the management of patients with LTCs or multimorbidity.
慢性疼痛常与其他长期病症（LTCs）同时出现，但我们对此的了解，尤其是与多重疾病（≥2种LTCs）相关的了解却很匮乏。我们旨在研究慢性疼痛的存在/程度与所经历的LTCs类型/数量之间的关联。
我们在英国生物银行的参与者（n = 500,295）中研究了LTCs的数量/类型（N = 45）与自我报告的在七个身体部位持续≥3个月的慢性疼痛或广泛性慢性疼痛之间的关系。使用逻辑回归比较慢性疼痛部位的存在/程度的相对风险比（RRR），并对社会人口统计学（性别/年龄/社会经济地位）和生活方式因素（吸烟/饮酒量/体重指数/身体活动）进行了调整。
218,648名参与者自我报告有慢性疼痛。其中，69.1%报告有≥1种LTC，36.2%报告有≥2种LTC。在所研究的45种LTC中的31种中，超过50%的参与者经历过慢性疼痛。慢性疼痛在偏头痛/头痛和肠易激综合征（疼痛是主要症状）中很常见，但在心理健康状况和消化系统疾病中也很常见。患有>4种LTC的参与者患慢性疼痛的可能性是没有LTC的参与者的三倍多（RRR 3.56，95%置信区间（CIs）3.44 - 3.68），患广泛性慢性疼痛的可能性是没有LTC的参与者的20倍（RRR 20.13，95% CI 18.26 - 22.19）。
慢性疼痛在广泛的LTCs中极为常见。患有多重疾病的人患更广泛慢性疼痛的风险更高。这些结果表明，慢性疼痛是管理患有LTCs或多重疾病的患者时需要考虑的关键因素。
