Chen Ju-Yi, Chen Tse-Wei, Lu Wei-Da
Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Front Med (Lausanne). 2021 Dec 24;8:786779. doi: 10.3389/fmed.2021.786779. eCollection 2021.
The HATCH score has been evaluated for predicting new onset atrial fibrillation, but never for adverse systemic thromboembolic events (STE) in elderly. We aimed to evaluate the HATCH score and comparing to atrial high rate episodes (AHRE) ≥24 h for predicting STE in older patients with cardiac implantable electronic devices (CIED) implantation. We retrospective enrolled 219 consecutive patients ≥ 65 years of age undergoing CIED implantation. The primary endpoint was subsequent STE. For all patients in the cohort, the CHADS-VASc, CHEST, mCHEST, HAVOC, HATCH scores and AHRE ≥ 24 h were determined. AHRE was defined as > 175 bpm lasting ≥ 30 s. Multivariate Cox regression analysis with time-dependent covariates was used to determine variables associated with independent risk of STE. The median patient age was 77 years, and 61.2% of the cohort was male. During follow-up (median, 35 months), 16 STE occurred (incidence rate, 2.51/100 patient-years; 95% CI, 1.65-5.48). Multiple Cox regression analysis showed that the HATCH score (HR, 3.405; 95% CI, 2.272-5.104; < 0.001) was an independent predictor for STE. The optimal HATCH score cutoff value was 3, with the highest Youden index (AUC, 0.907; 95% CI, 0.853-0.962; < 0.001). The STE rate increased with increasing HATCH score ( < 0.001). This study is the first to show the prognostic value of the HATCH score for STE occurrence in older patients with CIEDs.
HATCH评分已被评估用于预测新发房颤,但从未用于预测老年人的不良全身性血栓栓塞事件(STE)。我们旨在评估HATCH评分,并与≥24小时的房性高频率发作(AHRE)进行比较,以预测接受心脏植入式电子设备(CIED)植入的老年患者的STE。我们回顾性纳入了219例连续接受CIED植入的≥65岁患者。主要终点是随后发生的STE。对队列中的所有患者,确定CHADS-VASc、CHEST、mCHEST、HAVOC、HATCH评分以及≥24小时的AHRE。AHRE定义为心率>175次/分钟持续≥30秒。采用具有时间依赖性协变量的多变量Cox回归分析来确定与STE独立风险相关的变量。患者中位年龄为77岁,队列中61.2%为男性。在随访期间(中位时间为35个月),发生了16例STE(发生率为2.51/100患者年;95%CI,1.65 - 5.48)。多变量Cox回归分析显示,HATCH评分(HR,3.405;95%CI,2.272 - 5.104;P<0.001)是STE的独立预测因子。HATCH评分的最佳截断值为3,此时约登指数最高(AUC,0.907;95%CI,0.853 - 0.962;P<0.001)。STE发生率随HATCH评分升高而增加(P<0.001)。本研究首次表明HATCH评分对接受CIED植入的老年患者发生STE具有预后价值。