Albarracín Ana L, Farfán Fernando D
Departamento de Bioingeniería, Facultad de Ciencias Exactas y Tecnología, Laboratorio de Investigaciones en Neurociencias y Tecnologías Aplicadas (LINTEC), Universidad Nacional de Tucumán, Tucumán, Argentina.
Instituto Superior de Investigaciones Biológicas (INSIBIO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Tucumán, Argentina.
Data Brief. 2021 Dec 16;40:107712. doi: 10.1016/j.dib.2021.107712. eCollection 2022 Feb.
Parkinson's disease (PD) is currently diagnosed based on characteristic motor dysfunctions induced by the loss of dopaminergic neurons in the substantia nigra pars compacta [1], [2]. The animal model most commonly used to reproduce PD-related motor deficits in rats is the massive degeneration of nigrostriatal neurons by using intracerebral infusion of 6-hydroxydopamine (6-OHDA) [3], [4]. This article presents data related to the research article "Quantifying muscle alterations in a Parkinson's disease animal model using electromyographic biomarkers" [5]. This study evaluated the effect of PD neurotoxic lesion model on muscle function of freely moving rats. The effects on muscle function considering the time post-lesion have never been described for this Parkinson's disease model. Electromyographic recordings were obtained from control and hemiparkinsonian rats walking in a circular treadmill. Chronic EMG electrodes were implanted subcutaneously in a hindlimb muscle - the biceps femoris muscle - for evaluating muscular activity during the gait. Five dataset of EMG recordings are presented in this article corresponding to control animals and four groups of lesioned animals at different time post-injury (three to six weeks after lesion). Stationarity of the EMG signals were established and the effective muscular contractions were detected by using signal processing methods described in [5]. Power spectrum density was characterized through the mean and median frequencies and signals probability distribution function analysis was also performed.These analyses have shown that PSD frequency contents progressively fall with time post-lesion suggesting muscle function changes along this enclosed time. This dataset could be reused to investigate muscular activation parameters under control and lesioned conditions in freely moving rats and for evaluating different signal processing methods for EMG patterns detection.
帕金森病（PD）目前是根据黑质致密部多巴胺能神经元缺失所引发的特征性运动功能障碍来进行诊断的[1,2]。在大鼠中最常用于重现与PD相关运动缺陷的动物模型，是通过脑内注射6-羟基多巴胺（6-OHDA）使黑质纹状体神经元大量变性[3,4]。本文呈现了与研究论文《使用肌电图生物标志物量化帕金森病动物模型中的肌肉改变》[5]相关的数据。本研究评估了PD神经毒性损伤模型对自由活动大鼠肌肉功能的影响。对于这种帕金森病模型，从未描述过损伤后不同时间对肌肉功能的影响。从在圆形跑步机上行走的对照大鼠和偏侧帕金森病大鼠身上获取肌电图记录。将慢性肌电图电极皮下植入后肢肌肉——股二头肌——以评估步态期间的肌肉活动。本文呈现了五组肌电图记录数据集，分别对应对照动物以及损伤后不同时间（损伤后三到六周）的四组损伤动物。通过使用[5]中描述的信号处理方法，确定了肌电图信号的平稳性并检测到有效的肌肉收缩。通过平均频率和中位数频率对功率谱密度进行了表征，还进行了信号概率分布函数分析。这些分析表明，功率谱密度频率成分随损伤后时间逐渐下降，提示在这段时间内肌肉功能发生了变化。该数据集可重新用于研究自由活动大鼠在对照和损伤条件下的肌肉激活参数，以及评估用于肌电图模式检测的不同信号处理方法。
