Jang Hyemin, Yeo Minyoung, Cho Jinju, Kim Seonwoo, Chin Juhee, Kim Hee Jin, Seo Sang Won, Na Duk L
Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea.
Neuroscience Center Seoul South Korea.
Alzheimers Dement (N Y). 2021 Dec 31;7(1):e12209. doi: 10.1002/trc2.12209. eCollection 2021.
We investigated whether cognitive function improves in elderly individuals after Application-based Cognitive Training at Home (ACTH) for 12 months.
A total of 389 non-demented elderly volunteers aged over 60 years were recruited and randomly assigned to the intervention or control group. The intervention group underwent daily ACTH (with regular feedback from the administrator) and monthly offline cognitive training in groups for 12 months. All participants received a computerized cognitive test battery called Inbrain Cognitive Screening Test (Inbrain-CST) at baseline and 6 and 12 months. The primary outcome was the change in the total composite score of Inbrain-CST, and secondary outcomes included changes in composite scores in five cognitive domains of Inbrain-CST.
The intervention group outperformed the control group in terms of the total score ( = .001) and subscores of language ( < .001) and memory ( < .001) domains at 12 months.
ACTH improved global cognition in community-dwelling non-demented elderly individuals.
我们研究了居家应用认知训练（ACTH）12个月后，老年人的认知功能是否会改善。
共招募了389名60岁以上的非痴呆老年志愿者，并将他们随机分为干预组或对照组。干预组每天进行ACTH训练（管理员定期给予反馈），并每月进行一次线下小组认知训练，为期12个月。所有参与者在基线时、6个月和12个月时均接受了一项名为Inbrain认知筛查测试（Inbrain-CST）的计算机化认知测试组合。主要结局是Inbrain-CST总综合得分的变化，次要结局包括Inbrain-CST五个认知领域综合得分的变化。
在12个月时，干预组在总分（P = 0.001）以及语言（P < 0.001）和记忆（P < 0.001）领域的子得分方面均优于对照组。
ACTH改善了社区居住的非痴呆老年人的整体认知。
