Nghiem Tracy, Chougui Khadidja, Michalovic Alisha, Lalloo Chitra, Stinson Jennifer, Lafrance Marie-Elaine, Palomo Telma, Dahan-Oliel Noémi, Tsimicalis Argerie
Ingram School of Nursing, McGill University, Montreal, Quebec, Canada.
Shriners Hospitals for Children-Canada, Montreal, Quebec, Canada.
Can J Pain. 2018 Jan 30;2(1):9-20. doi: 10.1080/24740527.2017.1422115. eCollection 2018.
: Pain is a common symptom of osteogenesis imperfecta (OI) among children and adolescents. However, little is currently known of the pain experiences of adults with OI. : The aims of this study were to critically appraise the studies assessing OI pain, to synthesize the pain experiences of adults with OI, and to compare the adult OI pain experiences to childhood. : An integrative review was conducted. Five electronic bibliographic databases were searched. Published quantitative, qualitative, and/or mixed-method studies assessing pain in adults with OI were screened, reviewed, and appraised. Descriptive statistics were used to calculate quality scores, summarize sample characteristics, and synthesize findings. Extracted pain data were analyzed using constant comparison and consolidated into meaningful themes. : From the 832 titles identified, 14 studies including seven case reports met the inclusion criteria. Study appraisal scores ranged from low to moderate using the Quality Assessment Tool and the Case Report Checklist. The majority of studies assessed pain as a secondary outcome (71.4%) using well-established tools (64.2%). Adults with OI experience pain of mild to moderate intensity, which may interfere with completion of daily activities. Two themes emerged from analysis of the data: mild chronic pain persists despite surgical, pharmacological, or nonpharmacological interventions and past fractures and structural deformities may trigger onset of chronic pain in adulthood. : Limited attention has been given to exploring the pain experience of adults diagnosed with OI. Pain is a long-term symptom of OI requiring further in-depth investigation to better understand and manage pain in adults with OI.
疼痛是儿童和青少年成骨不全症（OI）的常见症状。然而，目前对于成年OI患者的疼痛体验知之甚少。
本研究的目的是严格评估评估OI疼痛的研究，综合成年OI患者的疼痛体验，并将成年OI患者的疼痛体验与儿童时期进行比较。
进行了一项综合综述。检索了五个电子文献数据库。对已发表的评估成年OI患者疼痛的定量、定性和/或混合方法研究进行了筛选、审查和评估。使用描述性统计来计算质量得分、总结样本特征并综合研究结果。使用持续比较法对提取的疼痛数据进行分析，并归纳为有意义的主题。
从识别出的832个标题中，有14项研究（包括7篇病例报告）符合纳入标准。使用质量评估工具和病例报告清单，研究评估分数从低到中等。大多数研究（71.4%）使用成熟的工具（64.2%）将疼痛作为次要结果进行评估。成年OI患者经历轻度至中度强度的疼痛，这可能会干扰日常活动的完成。数据分析得出两个主题：尽管进行了手术、药物或非药物干预，但轻度慢性疼痛仍然存在，过去的骨折和结构畸形可能会引发成年期慢性疼痛的发作。
对于探索成年OI患者的疼痛体验，关注有限。疼痛是OI的长期症状，需要进一步深入研究，以更好地理解和管理成年OI患者的疼痛。
