Suppr超能文献

足月新生儿高钠血症脱水患者的评估

Evaluation of Term Newborn Patients With Hypernatremic Dehydration.

作者信息

Akdeniz Osman, Çelik Muhittin, Samancı Serhat

机构信息

Department of Pediatrics, Diyarbakir Children's Hospital, Diyarbakir, Turkey.

出版信息

Turk Arch Pediatr. 2021 Jul 1;56(4):344-349. doi: 10.5152/TurkArchPediatr.2021.20153. eCollection 2021 Jul.

Abstract

AIM

We aimed to evaluate the demographic, clinical, and laboratory findings and the management of newborns with hypernatremic dehydration (HDH).

MATERIALS AND METHODS

A total of 85 term newborns with serum sodium (Na) levels higher than 145 mEq/L who admitted to our hospital between January 2011 and December 2018 were included in this study.

RESULTS

Among all cases, 54.1% were female infants with the mean birth weight, weight loss ratio, and median age at diagnosis of 3095 ± 540 g, 13.6 ± 10%, and 8 (2-24) days, respectively. The most common presenting complaints were breastfeeding difficulties (90.5%), fever (63.5%), decreased urination (43.5%), jaundice (22.3%), and convulsion (15.3%). The mean sodium and potassium, and median blood urea and creatinine levels on admission were 167.9 ± 13.4 mEq/L, 5.4 ± 2.8 mmol/L, 213 mg/dL (11-476 mg/dL), and 2.4 mg/dL (0.52-9.96 mg/dL), respectively. There was metabolic acidosis in 67% and acute renal failure in 74.4% of patients, while peritoneal dialysis was performed in 12 of them. There was a positive correlation between weight loss ratio and admission age, serum urea, and creatinine levels; there was a negative correlation between weight loss and blood pH. Eight patients died (9.4%).

CONCLUSIONS

In our study, serum urea, creatinine, potassium, metabolic acidosis levels, convulsion, and dialysis requirements at the time of admission of the newborns with HDH were found to be higher in those who died compared to those who survived. Convulsion was a presenting complaint, and it was also observed during the treatment.

摘要

目的

我们旨在评估高钠血症性脱水(HDH)新生儿的人口统计学、临床和实验室检查结果以及治疗情况。

材料与方法

本研究纳入了2011年1月至2018年12月期间入住我院的85例足月新生儿,其血清钠(Na)水平高于145 mEq/L。

结果

在所有病例中,54.1%为女婴,诊断时的平均出生体重、体重减轻率和中位年龄分别为3095±540 g、13.6±10%和8(2 - 24)天。最常见的主诉是母乳喂养困难(90.5%)、发热(63.5%)、尿量减少(43.5%)、黄疸(22.3%)和惊厥(15.3%)。入院时的平均钠和钾水平以及中位血尿素和肌酐水平分别为167.9±13.4 mEq/L、5.4±2.8 mmol/L、213 mg/dL(11 - 476 mg/dL)和2.4 mg/dL(0.52 - 9.96 mg/dL)。67%的患者存在代谢性酸中毒,74.4%的患者存在急性肾衰竭,其中12例患者进行了腹膜透析。体重减轻率与入院年龄、血清尿素和肌酐水平呈正相关;体重减轻与血液pH值呈负相关。8例患者死亡(9.4%)。

结论

在我们的研究中,发现与存活的HDH新生儿相比,死亡新生儿入院时的血清尿素、肌酐、钾、代谢性酸中毒水平、惊厥和透析需求更高。惊厥是一种主诉,在治疗过程中也有观察到。

相似文献

1
Evaluation of Term Newborn Patients With Hypernatremic Dehydration.
Turk Arch Pediatr. 2021 Jul 1;56(4):344-349. doi: 10.5152/TurkArchPediatr.2021.20153. eCollection 2021 Jul.
2
Breast-feeding-associated hypernatremia: retrospective analysis of 169 term newborns.
Pediatr Int. 2008 Feb;50(1):29-34. doi: 10.1111/j.1442-200X.2007.02507.x.
3
Moderate hypernatremic dehydration in newborn infants: retrospective evaluation of 64 cases.
J Matern Fetal Neonatal Med. 2007 Jun;20(6):449-52. doi: 10.1080/14767050701398256.
4
Clinical Profile and Outcome of Young Infants With Hypernatremic Dehydration Presenting to the Emergency Department.
Pediatr Emerg Care. 2024 Apr 1;40(4):e10-e15. doi: 10.1097/PEC.0000000000003028. Epub 2023 Aug 15.
5
Comparison of oral and intravenous fluid therapy in newborns with hypernatremic dehydration.
J Matern Fetal Neonatal Med. 2014 Mar;27(5):491-4. doi: 10.3109/14767058.2013.819334. Epub 2013 Jul 30.
8
Hypernatremic dehydration in the newborn period and long-term follow up.
Pediatr Int. 2007 Feb;49(1):19-23. doi: 10.1111/j.1442-200X.2007.02313.x.
10
Hypernatremic Dehydration in Breastfed Term Infants: Retrospective Evaluation of 159 Cases.
Breastfeed Med. 2017 Jan/Feb;12:5-11. doi: 10.1089/bfm.2016.0077. Epub 2016 Dec 19.

引用本文的文献

1
Increasing Sodium Variability in the First 96 Hours after Birth is Associated with Adverse In-Hospital Outcomes of Preterm Newborns.
Curr Dev Nutr. 2022 Dec 27;7(1):100026. doi: 10.1016/j.cdnut.2022.100026. eCollection 2023 Jan.

本文引用的文献

1
Treatment of Hypernatremia in Breastfeeding Neonates: A Systematic Review.
Biomed Hub. 2017 Jan 27;2(1):1-10. doi: 10.1159/000454980. eCollection 2017 Jan-Apr.
2
Turkish Neonatal Society Guideline on fluid and electrolyte balance in the newborn.
Turk Pediatri Ars. 2018 Dec 25;53(Suppl 1):S55-S64. doi: 10.5152/TurkPediatriArs.2018.01807. eCollection 2018.
3
The Turkish Neonatal Jaundice Online Registry: A national root cause analysis.
PLoS One. 2018 Feb 23;13(2):e0193108. doi: 10.1371/journal.pone.0193108. eCollection 2018.
6
Hypernatremic Dehydration in Breastfed Term Infants: Retrospective Evaluation of 159 Cases.
Breastfeed Med. 2017 Jan/Feb;12:5-11. doi: 10.1089/bfm.2016.0077. Epub 2016 Dec 19.
7
Neonatal Acute Kidney Injury.
Pediatrics. 2015 Aug;136(2):e463-73. doi: 10.1542/peds.2014-3819. Epub 2015 Jul 13.
9
Breast-feeding-associated hypernatremia: retrospective analysis of 169 term newborns.
Pediatr Int. 2008 Feb;50(1):29-34. doi: 10.1111/j.1442-200X.2007.02507.x.
10
[Hypernatremic dehydration in children: retrospective study of 105 cases].
Arch Pediatr. 2005 Dec;12(12):1697-702. doi: 10.1016/j.arcped.2005.07.019. Epub 2005 Oct 10.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验