Araujo L I, Camici P, Spinks T, Jones T, Maseri A
MRC Cyclotron Unit, Hammersmith Hospital, London, United Kingdom.
Am J Cardiol. 1987 Nov 16;60(15):26H-30H. doi: 10.1016/0002-9149(87)90547-9.
Myocardial uptake of the glucose analog F-18-2-fluoro-2-deoxy-D-glucose (FDG) was assessed by positron emission tomography in 6 normal volunteers, 7 patients with chronic stable angina and 22 patients with unstable angina at rest in fasting conditions. Regional myocardial perfusion was assessed by rubidium-82. The study was repeated a few days later after intravenous infusion of isosorbide dinitrate. FDG uptake was similar in control subjects and patients with stable angina (0.023 +/- 0.032 vs 0.012 +/- 0.008 mol/ml/min, p less than 0.42) but was about 4-fold higher on the average in patients with unstable angina (0.084 +/- 0.047, p less than 0.01). The severity of coronary obstructions in stable and unstable angina patients was similar. The increased uptake involved the whole heart, including areas not distal to critically stenosed vessels; it was not associated with reduced myocardial perfusion and was not related to a recent episode of transient ischemia as assessed by symptoms and by Holter monitoring. After continuous infusion of nitrates, FDG uptake was consistently and significantly reduced toward normal levels both in areas perfused by critically stenosed coronary arteries and by noncritically stenosed vessels.
在空腹静息状态下，通过正电子发射断层扫描评估了6名正常志愿者、7名慢性稳定型心绞痛患者和22名不稳定型心绞痛患者对葡萄糖类似物F-18-2-氟-2-脱氧-D-葡萄糖（FDG）的心肌摄取情况。用铷-82评估局部心肌灌注。在静脉输注硝酸异山梨酯几天后重复该研究。对照组受试者和稳定型心绞痛患者的FDG摄取相似（分别为0.023±0.032与0.012±0.008摩尔/毫升/分钟，p<0.42），但不稳定型心绞痛患者的FDG摄取平均约高4倍（0.084±0.047，p<0.01）。稳定型和不稳定型心绞痛患者的冠状动脉阻塞严重程度相似。摄取增加累及整个心脏，包括严重狭窄血管远端以外的区域；它与心肌灌注减少无关，也与通过症状和动态心电图监测评估的近期短暂性缺血发作无关。持续输注硝酸盐后，在严重狭窄冠状动脉灌注区域和非严重狭窄血管灌注区域，FDG摄取均持续且显著降低至正常水平。
