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精准医学与团结(及正义)的碎片化。

Precision medicine and the fragmentation of solidarity (and justice).

机构信息

Center for Bioethics and Social Justice, College of Human Medicine, Michigan State University, 965 Wilson Road C-208, East Lansing, MI, 48824, USA.

出版信息

Med Health Care Philos. 2022 Jun;25(2):191-206. doi: 10.1007/s11019-022-10067-2. Epub 2022 Jan 10.

Abstract

Solidarity is a fundamental social value in many European countries, though its precise practical and theoretical meaning is disputed. In a health care context, I agree with European writers who take solidarity normatively to mean roughly equal access to effective health care for all. That is, solidarity includes a sense of justice. Given that, I will argue that precision medicine represents a potential weakening of solidarity, albeit not a unique weakening. Precision medicine includes 150 targeted cancer therapies (mostly for metastatic cancer), all of which are extraordinarily expensive. Our critical question: Must a commitment to solidarity as defined mean that all these targeted cancer therapies should be guaranteed to all within each country in the European Union, no matter the cost, no matter the degree of effectiveness? Such a commitment would imply that cancer was ethically special, rightfully commandeering unlimited resources. That in itself would undermine solidarity. I offer multiple examples of how current and future dissemination of these targeted cancer drugs threaten a commitment to solidarity. An alternative is to fund more cancer prevention efforts. However, that too proves a threat to solidarity. Solidarity, with or without a sense of justice, is too abstract a notion to address these challenges. Further, we need to accept that we can only hope to achieve "rough justice" and "supple solidarity." The precise practical meaning of these notions needs to be worked out through a fair and inclusive process of rational democratic deliberation, which is the real and practical foundation of just solidarity.

摘要

团结是许多欧洲国家的基本社会价值观,尽管其确切的实践和理论意义存在争议。在医疗保健背景下,我同意欧洲作家的观点,即规范性地将团结理解为大致意味着所有人都能平等获得有效的医疗保健。也就是说,团结包括正义感。基于此,我将论证精准医学代表了团结的潜在削弱,尽管不是唯一的削弱。精准医学包括 150 种针对癌症的靶向疗法(主要针对转移性癌症),这些疗法都非常昂贵。我们的关键问题是:作为定义的团结承诺是否意味着所有这些针对癌症的疗法都应该在欧盟的每个国家无条件地保障给所有人,无论成本如何,无论有效性程度如何?这样的承诺将意味着癌症在伦理上是特殊的,理应征用无限的资源。这本身就会破坏团结。我提供了多个例子,说明这些靶向癌症药物的当前和未来传播如何威胁到对团结的承诺。另一种选择是为更多的癌症预防工作提供资金。然而,这也对团结构成威胁。团结,无论是否有正义感,都是一个过于抽象的概念,无法应对这些挑战。此外,我们必须接受,我们只能希望实现“大致正义”和“灵活团结”。这些概念的精确实践意义需要通过公平和包容的理性民主审议过程来制定,这是公正团结的真正和实践基础。

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