Jira M, Strejcek J, Chodounsky Z, Fuchsova M, Tomasova M, Faltyn J, Suchomelova M
Department of Medizine, Faculty of Medicine and Hygiene, Charles University, Prague, Czechoslovakia.
Arch Geschwulstforsch. 1987;57(5):379-84.
Natural killer activity against K562 targets and recombinant interleukin-2 induced cytotoxicity to NK resistant targets (MEL-4 and T24) was investigated in 15 melanoma patients. Before elective surgery no differences in cytotoxic activities were demonstrated when compared with patients with colorectal adenocarcinoma and controls. No correlation with the depth of the melanoma lesion was observed. Numbers of precursors of IL-2 induced killers in melanoma patients were in normal range. In conclusion, no defects in non-specific NK and IL-2 induced behavior in peripheral blood of melanoma patients were found. Other factors, specific, non-specific, related or unrelated to the tumor side should be thus considered.
对15例黑色素瘤患者研究了其对K562靶标的自然杀伤活性以及重组白细胞介素-2诱导的对NK抗性靶标（MEL-4和T24）的细胞毒性。在择期手术前，与结肠直肠腺癌患者和对照组相比，未显示出细胞毒性活性有差异。未观察到与黑色素瘤病变深度的相关性。黑色素瘤患者中白细胞介素-2诱导杀伤细胞的前体数量在正常范围内。总之，未发现黑色素瘤患者外周血中非特异性NK和白细胞介素-2诱导行为存在缺陷。因此应考虑其他与肿瘤相关或不相关的特异性或非特异性因素。
