State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
University of Science and Technology of China, Hefei, Anhui 230026, China.
ACS Appl Bio Mater. 2021 Jun 21;4(6):5266-5275. doi: 10.1021/acsabm.1c00410. Epub 2021 Jun 10.
A theranostic nanoagent exhibits great promise to improve diagnostic accuracy and therapy efficacy. Herein, a kind of theranostic nanoagent based on poly(vinylpyrrolidone) (PVP)-protected ultrasmall CuO nanoparticles (CuO NPs) is developed by a facile liquid reduction method. Attributed to high near-infrared absorbance and good biocompatibility, CuO NPs have shown significant potential for photothermal therapy. Moreover, CuO NPs with a satisfactory relaxivity coefficient () can be well applied as outstanding MRI contrast agents and exhibit excellent magnetic resonance imaging (MRI) ability. treatments further demonstrate that CuO NPs could be well used as multifunctional theranostic nanoagents, which achieve precise MRI and a high photothermal antitumor effect. It is expected to further promote the research and application of copper-based nanoparticles as theranostic nanoagents for cancer therapy.
一种基于聚维酮（PVP）保护的超小氧化铜纳米粒子（CuO NPs）的治疗诊断纳米制剂通过一种简便的液相还原法得以开发。由于具有高近红外吸收率和良好的生物相容性，CuO NPs 在光热治疗方面表现出了巨大的潜力。此外，CuO NPs 的弛豫率系数（）令人满意，可用作杰出的磁共振成像（MRI）对比剂，并表现出优异的磁共振成像（MRI）能力。联合治疗进一步证明，CuO NPs 可作为多功能治疗诊断纳米制剂，实现精确的 MRI 和高的光热抗肿瘤效果。有望进一步推动基于铜的纳米粒子作为癌症治疗治疗诊断纳米制剂的研究和应用。
