School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China; Condensed Matter Science and Technology Institute, Harbin Institute of Technology, Harbin, 150001, China; Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, 8000, Denmark.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
Biomaterials. 2017 Oct;141:284-295. doi: 10.1016/j.biomaterials.2017.06.033. Epub 2017 Jun 23.
Biocompatible single-component theranostic agents integrating multimodal imaging and therapeutic functions (namely, "all-in one" agents) are highly desired for clinical cancer treatments. Herein, PEGylated pure metallic bismuth nanocrystals (Bi-PEG NCs) have been developed to be a competent theranostic agent for in vivo high-performance multimodal bio-imaging and photothermal ablation of tumors. The resultant Bi-PEG NCs show excellent physiological stability, biocompatibility, prolonged blood circulation half-life and preferential tumor accumulation. Thanking to the strong near-infrared (NIR) absorbance as well as the high photothermal conversion efficiency and conversion stability, highly effective in vivo photothermal ablation on tumors has been realized upon NIR irradiation, without noticeable toxicity. Impressively, the Bi-PEG NCs show ultrahigh X-ray computed topography (CT) enhancement efficiency (∼60.3 HU mL mg), overwhelming all CT contrast agents reported so far. Combining the strong CT contrast ability and photoacoustic/photothermal effect, high-contrast CT, photoacoustic (PA) and infrared thermal (IRT) triple-modal imaging have been demonstrated both in vitro and in vivo. This work highlights the potentials of such NCs as a powerful "all-in-one" theranostic nanoplatform for bioimaging and antitumor therapy, and may have provided a rather promising candidate for clinically-applied antitumor treatments based on single-component agents.
用于临床癌症治疗的生物相容的单组分治疗诊断一体化试剂，即“一体化”试剂，高度期望将多种模式成像和治疗功能集成在单一试剂中。在此，我们开发了聚乙二醇化纯金属铋纳米晶体（Bi-PEG NCs），作为用于体内高性能多模式生物成像和肿瘤光热消融的治疗诊断一体化试剂。所得的 Bi-PEG NCs 表现出优异的生理稳定性、生物相容性、延长的血液循环半衰期和优先的肿瘤积累。由于具有很强的近红外（NIR）吸收以及高光热转换效率和转换稳定性，在近红外照射下实现了高效的体内肿瘤光热消融，而没有明显的毒性。令人印象深刻的是，Bi-PEG NCs 表现出超高的 X 射线计算机断层扫描（CT）增强效率（∼60.3 HU mL mg），超过了迄今为止报道的所有 CT 造影剂。结合强 CT 对比能力和光声/光热效应，在体外和体内均证明了高对比度 CT、光声（PA）和红外热（IRT）三模态成像。这项工作突出了这些 NCs 作为一种强大的“一体化”治疗诊断纳米平台用于生物成像和抗肿瘤治疗的潜力，并可能为基于单一组分试剂的临床应用抗肿瘤治疗提供了一种很有前途的候选物。
