Hu Ping, Hou Xu, Yu Xiaojun, Wei Xuguo, Li Yang, Yang Dawei, Jiang Xiaohong
Zhong Yuan Academy of Biological Medicine, Liaocheng People's Hospital, Liaocheng 252000, China.
Department of Hepatobiliary Surgery, Liaocheng People's Hospital, Liaocheng 252000, China.
ACS Appl Bio Mater. 2021 Jun 21;4(6):4862-4871. doi: 10.1021/acsabm.1c00171. Epub 2021 May 18.
Fabrication of multifunctional nanoprobes, which integrate tumor targeting, imaging, and effective treatment, has been widely explored in nanomedicine. In the present study, we fabricated tumor-targeting polymer folic acid-terminated polyethylene glycol thiol-modified gold nanostars (GNS-FA), which could realize X-ray computed tomography (CT) imaging and PTT/RT synergistic therapy. The synthesized GNS-FA exhibited good biocompatibility. GNS-FA could be used as a CT imaging contrast agent due to the strong X-ray attenuation of Au. GNS-FA exhibited good near-infrared (NIR) light absorption and excellent photothermal conversion performance, making them promising photothermal transduction agents (PTAs). Furthermore, GNS-FA could be used as an RT sensitizer to enhance the radio-mediated cell death due to the high atomic number (high ) of gold. Hence, GNS-FA were used as the CT imaging agent, PTA, and radiosensitizer in this work. The in vitro antitumor experiments showed that the PTT/RT combined treatment had enhanced anticancer efficacy compared with the monotherapy (PTT or RT). Our results indicated that the bioconjugated GNS could offer an excellent nanoplatform for CT imaging-guided PTT/RT combined cancer therapy in the future.
多功能纳米探针的制备，其整合了肿瘤靶向、成像和有效治疗，已在纳米医学中得到广泛探索。在本研究中，我们制备了肿瘤靶向聚合物叶酸末端聚乙二醇硫醇修饰的金纳米星（GNS-FA），其可实现X射线计算机断层扫描（CT）成像和光热疗法/放射疗法（PTT/RT）协同治疗。合成的GNS-FA表现出良好的生物相容性。由于金具有强烈的X射线衰减，GNS-FA可作为CT成像造影剂。GNS-FA表现出良好的近红外（NIR）光吸收和优异的光热转换性能，使其成为有前景的光热转导剂（PTA）。此外，由于金的高原子序数（高 ），GNS-FA可作为RT增敏剂来增强放射介导的细胞死亡。因此，在本工作中GNS-FA被用作CT成像剂、PTA和放射增敏剂。体外抗肿瘤实验表明，与单一疗法（PTT或RT）相比，PTT/RT联合治疗具有增强的抗癌效果。我们的结果表明，生物共轭的GNS在未来可为CT成像引导的PTT/RT联合癌症治疗提供优异的纳米平台。
