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使用不同形状的金基纳米材料结合传统物理技术进行癌症治疗。

Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques.

作者信息

Tarantino Simona, Caricato Anna Paola, Rinaldi Rosaria, Capomolla Caterina, De Matteis Valeria

机构信息

Department of Mathematics and Physics "E. De Giorgi", University of Salento, Via Monteroni, 73100 Lecce, Italy.

National Institute of Nuclear Physics (INFN), Section of Lecce, Via Monteroni, 73100 Lecce, Italy.

出版信息

Pharmaceutics. 2023 Feb 2;15(2):500. doi: 10.3390/pharmaceutics15020500.

DOI:10.3390/pharmaceutics15020500
PMID:36839822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9968101/
Abstract

The conventional methods of cancer treatment and diagnosis, such as radiotherapy, chemotherapy, and computed tomography, have developed a great deal. However, the effectiveness of such methods is limited to the possible failure or collateral effects on the patients. In recent years, nanoscale materials have been studied in the field of medical physics to develop increasingly efficient methods to treat diseases. Gold nanoparticles (AuNPs), thanks to their unique physicochemical and optical properties, were introduced to medicine to promote highly effective treatments. Several studies have confirmed the advantages of AuNPs such as their biocompatibility and the possibility to tune their shapes and sizes or modify their surfaces using different chemical compounds. In this review, the main properties of AuNPs are analyzed, with particular focus on star-shaped AuNPs. In addition, the main methods of tumor treatment and diagnosis involving AuNPs are reviewed.

摘要

癌症治疗和诊断的传统方法，如放射疗法、化学疗法和计算机断层扫描，已经有了很大的发展。然而，这些方法的有效性受到可能的失败或对患者的附带影响的限制。近年来，纳米级材料在医学物理领域得到了研究，以开发越来越有效的疾病治疗方法。金纳米颗粒（AuNPs）由于其独特的物理化学和光学性质，被引入医学以促进高效治疗。多项研究证实了金纳米颗粒的优势，如它们的生物相容性以及使用不同化合物调节其形状和大小或修饰其表面的可能性。在这篇综述中，分析了金纳米颗粒的主要性质，特别关注星形金纳米颗粒。此外，还综述了涉及金纳米颗粒的肿瘤治疗和诊断的主要方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/1409337cae50/pharmaceutics-15-00500-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/10ba4504f181/pharmaceutics-15-00500-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/c3aecc290d0b/pharmaceutics-15-00500-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/0c609eb2a7de/pharmaceutics-15-00500-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/e48d3760def0/pharmaceutics-15-00500-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/43aa152a9593/pharmaceutics-15-00500-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/f2017b25056e/pharmaceutics-15-00500-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/31c16d0ef769/pharmaceutics-15-00500-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/47fe14389a80/pharmaceutics-15-00500-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/15d875492c6e/pharmaceutics-15-00500-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/c7be34f6e181/pharmaceutics-15-00500-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/4cbcebc800cc/pharmaceutics-15-00500-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/d965d7b73740/pharmaceutics-15-00500-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/dbf534e90033/pharmaceutics-15-00500-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/bee3134f9200/pharmaceutics-15-00500-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/1409337cae50/pharmaceutics-15-00500-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/10ba4504f181/pharmaceutics-15-00500-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/c3aecc290d0b/pharmaceutics-15-00500-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/0c609eb2a7de/pharmaceutics-15-00500-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/e48d3760def0/pharmaceutics-15-00500-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/43aa152a9593/pharmaceutics-15-00500-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/f2017b25056e/pharmaceutics-15-00500-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/31c16d0ef769/pharmaceutics-15-00500-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/47fe14389a80/pharmaceutics-15-00500-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/15d875492c6e/pharmaceutics-15-00500-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/c7be34f6e181/pharmaceutics-15-00500-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/4cbcebc800cc/pharmaceutics-15-00500-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/d965d7b73740/pharmaceutics-15-00500-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/dbf534e90033/pharmaceutics-15-00500-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/bee3134f9200/pharmaceutics-15-00500-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5525/9968101/1409337cae50/pharmaceutics-15-00500-g015.jpg

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本文引用的文献

[1]
Shining Gold Nanostars: From Cancer Diagnostics to Photothermal Treatment and Immunotherapy.

J Immunol Sci. 2018

[2]
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Nanoscale Adv. 2020-7-16

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Nanoscale Adv. 2019-5-27

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Clinical translation of gold nanoparticles.

Drug Deliv Transl Res. 2023-2

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