Department of Physiology, All India Institute of Medical Sciences (AIIMS), Deoghar, India.
StepOne NGO, Bengaluru, India.
Gynecol Endocrinol. 2022 Apr;38(4):288-295. doi: 10.1080/09513590.2021.2025217. Epub 2022 Jan 10.
Altered irisin levels have been reported in pregnancy-associated disorders, such as preeclampsia.
A systematic review and meta-analysis were conducted to evaluate the changes in maternal circulatory irisin levels in preeclampsia as compared to normotensive healthy pregnant controls.
Relevant studies were identified by searching PubMed and other databases. Random-effects model was used to obtain standardized mean differences (SMDs) and its 95% confidence intervals (CIs). The sub-group meta-regression analyses were conducted to explore heterogeneity. The presence of publication bias and the study robustness was tested using funnel plot and sensitivity analyses, respectively.
This meta-analysis finally included 14 observations from eight studies. Compared with controls, preeclampsia patients showed significantly decreased serum irisin levels (SMD: -1.13; 95% CI: -1.63 to -0.62, < .0001). The sub-group analysis showed that this decrease in irisin is regardless of body mass index (BMI) and gestational age of preeclampsia patients. The meta-regression analysis indicated that blood pressure is significantly associated with the observed results. There was no significant publication bias as indicated by the funnel plot analysis followed by Begg's ( = .35) and Egger's tests ( = .39). The sensitivity analysis indicated that no single study had a significant influence on the overall outcome, suggesting the robustness of this meta-analysis.
This meta-analysis showed significantly decreased maternal serum irisin level in preeclampsia patients as compared to normotensive pregnant women. This study highlights the need for future studies evaluating the diagnostic utilities and associations of irisin with the fetal and neonatal outcomes in preeclampsia.
已有研究报道妊娠相关疾病（如子痫前期）存在鸢尾素水平改变。
系统评价和荟萃分析旨在评估子痫前期患者与正常血压健康孕妇相比母体循环鸢尾素水平的变化。
通过检索 PubMed 和其他数据库确定相关研究。采用随机效应模型获取标准化均数差（SMD）及其 95%置信区间（CI）。采用亚组meta 回归分析来探索异质性。采用漏斗图和敏感性分析分别检测发表偏倚和研究稳健性。
本荟萃分析最终纳入 8 项研究的 14 项观察结果。与对照组相比，子痫前期患者血清鸢尾素水平显著降低（SMD：-1.13；95%CI：-1.63 至-0.62， < .0001）。亚组分析表明，鸢尾素的这种降低与子痫前期患者的体重指数（BMI）和妊娠年龄无关。meta 回归分析表明血压与观察结果显著相关。漏斗图分析后 Begg 检验（ = .35）和 Egger 检验（ = .39）均提示无显著发表偏倚。敏感性分析表明，没有单个研究对总体结果有显著影响，提示本荟萃分析结果稳健。
与正常血压孕妇相比，子痫前期患者母体血清鸢尾素水平显著降低。本研究强调了未来研究评估鸢尾素在子痫前期中的诊断效用及其与胎儿和新生儿结局的相关性的必要性。
