Richardson J E, Gladman D D, Fam A, Keystone E C
University of Toronto Rheumatic Disease Unit, Ontario, Canada.
Arthritis Rheum. 1987 Nov;30(11):1293-7. doi: 10.1002/art.1780301113.
Forty-three patients with well-documented giant cell arteritis (GCA) were studied clinically and with HLA typing. All patients were over age 40. Twenty-two of the patients had coexistent polymyalgia rheumatica (PMR). No association with class I HLA antigens was detected. When compared with HLA findings in 243 healthy controls, HLA-DR4 was increased in patients with GCA and PMR, but not in patients with GCA alone. Pooled analysis of data from 4 published papers confirmed the association of DR4 with GCA and PMR (P much less than 0.00001). Patients with PMR but negative findings of temporal artery biopsies also showed an increased frequency of HLA-DR4, but this did not reach statistical significance, probably because of the small number of subjects. It is likely that the increased frequency of DR4 in GCA patients is related to its association with PMR.
对43例有充分记录的巨细胞动脉炎（GCA）患者进行了临床研究和HLA分型。所有患者年龄均超过40岁。其中22例患者合并有风湿性多肌痛（PMR）。未检测到与I类HLA抗原的关联。与243名健康对照的HLA结果相比，GCA合并PMR患者的HLA - DR4增加，但单纯GCA患者未增加。对4篇已发表论文的数据进行汇总分析证实了DR4与GCA和PMR的关联（P远小于0.00001）。颞动脉活检结果为阴性的PMR患者中，HLA - DR4的频率也有所增加，但未达到统计学意义，可能是因为样本量较小。GCA患者中DR4频率增加可能与其与PMR的关联有关。
