谷草转氨酶 1 作为人类癌症的一个潜在靶点。
Glutamic oxaloacetic transaminase 1 as a potential target in human cancer.
机构信息
Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
出版信息
Eur J Pharmacol. 2022 Feb 15;917:174754. doi: 10.1016/j.ejphar.2022.174754. Epub 2022 Jan 8.
Glutamic Oxaloacetic Transaminase 1 (GOT1) is one distinct isoenzyme of glutamic oxaloacetic transaminase in eukaryotic cells, which is located in the cytoplasm. To date, several studies have shown that GOT1 plays a critical role in regulating cell proliferation by participating in amino acid metabolism, especially in glutamine metabolism. In addition, GOT1 is overexpressed in many cancer, so GOT1 has been identified as a potentially therapeutic target. Herein, this review summarizes the structure and function of GOT1 and the important roles of GOT1 in some tumor progress, as well as the characterization of GOT1 inhibitors. It may provide new insight into the discovery of small compounds as potential anti-GOT1 drugs for treatment of cancer.
谷草转氨酶 1（GOT1）是真核细胞中谷草转氨酶的一种独特同工酶，位于细胞质中。迄今为止，已有多项研究表明，GOT1 通过参与氨基酸代谢，特别是谷氨酰胺代谢，在调节细胞增殖方面发挥着关键作用。此外，GOT1 在许多癌症中过度表达，因此 GOT1 已被确定为潜在的治疗靶点。本文综述了 GOT1 的结构和功能，以及 GOT1 在一些肿瘤进展中的重要作用，以及 GOT1 抑制剂的特征。这可能为发现作为潜在的抗 GOT1 药物的小分子化合物用于癌症治疗提供新的思路。
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