Peng Huan, Dou Huihong, He Sheng, Xie Yu-An, Zhang Qinle, Zheng Jianqiu
Birth Defects Prevention and Control Institute, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Guangxi Key Laboratory of Reproductive Health and Birth Defect Prevention, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Front Oncol. 2024 Dec 24;14:1519046. doi: 10.3389/fonc.2024.1519046. eCollection 2024.
GOT1, a cytoplasmic glutamic oxaloacetic transaminase, plays a critical role in various metabolic pathways essential for cellular homeostasis and dysregulated metabolism. Recent studies have highlighted the significant plasticity and roles of GOT1 in metabolic reprogramming through participating in both classical and non-classical glutamine metabolism, glycolytic metabolism, and other metabolic pathways. This review summarizes emerging insights on the metabolic roles of GOT1 in cancer cells and emphasizes the response of cancer cells to altered metabolism when the expression of GOT1 is altered. We review how cancer cells repurpose cell intrinsic metabolism and their flexibility when GOT1 is inhibited and delineate the molecular mechanisms of GOT1's interaction with specific oncogenes and regulators at multiple levels, including transcriptional and epigenetic regulation, which govern cellular growth and metabolism. These insights may provide new directions for cancer metabolism research and novel targets for cancer treatment.
谷草转氨酶1（GOT1）是一种细胞质谷氨酸草酰乙酸转氨酶，在细胞内稳态和代谢失调所必需的各种代谢途径中发挥关键作用。最近的研究强调了GOT1通过参与经典和非经典谷氨酰胺代谢、糖酵解代谢及其他代谢途径，在代谢重编程中具有显著的可塑性和作用。本综述总结了关于GOT1在癌细胞中代谢作用的新见解，并强调了GOT1表达改变时癌细胞对代谢改变的反应。我们回顾了GOT1被抑制时癌细胞如何重新利用细胞内在代谢及其灵活性，并阐述了GOT1在多个层面与特定癌基因和调节因子相互作用的分子机制，包括调控细胞生长和代谢的转录和表观遗传调控。这些见解可能为癌症代谢研究提供新方向，并为癌症治疗提供新靶点。
