Department of Radiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203 Berlin, Germany; Berlin Institute of Health (BIH), Anna-Louisa-Karsch-Str. 2, 10178 Berlin, Germany; Richard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, 830 South Wood Street, Chicago, IL 60612, United States.
Richard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, 830 South Wood Street, Chicago, IL 60612, United States.
Magn Reson Imaging. 2022 Apr;87:113-118. doi: 10.1016/j.mri.2022.01.005. Epub 2022 Jan 7.
To quantify the heterogeneity of viscoelastic tissue properties in prostatectomy specimens from men with prostate cancer (PC) using MR elastography (MRE) with histopathology as reference.
Twelve fresh prostatectomy specimens were examined in a preclinical 9.4T MRI scanner. Maps of the complex shear modulus (|G*| in kPa) with its real and imaginary part (G' and G" in kPa) were calculated at 500 Hz. Prostates were divided into 12 segments for segment-wise measurement of viscoelastic properties and histopathology. Coefficients of variation (CVs in %) were calculated for quantification of heterogeneity.
Group-averaged values of cancerous vs. benign segments were significantly increased: |G*| of 12.13 kPa vs. 6.14 kPa, G' of 10.84 kPa vs. 5.44 kPa and G" of 5.45 kPa vs. 2.92 kPa, all p < 0.001. In contrast, CVs were significantly increased for benign segments: 23.59% vs. 26.32% (p = 0.014) for |G*|, 27.05% vs. 37.84% (p < 0.003) for G', and 36.51% vs. 50.37% (p = 0.008) for G".
PC is characterized by a stiff yet homogeneous biomechanical signature, which may be due to the unique nondestructive growth pattern of PC with intervening stroma, providing a rigid scaffold in the affected area. In turn, increased heterogeneity in benign prostate segments may be attributable to the presence of different prostate zones with involvement by specific nonmalignant pathology.
利用磁共振弹性成像（MRE）与组织病理学对照，量化前列腺癌（PC）患者前列腺切除术标本中粘弹性组织特性的异质性。
在临床前 9.4T MRI 扫描仪中检查了 12 个新鲜前列腺切除术标本。在 500Hz 时计算出复剪切模量（|G*|，kPa）及其实部（G'，kPa）和虚部（G"，kPa）的图谱。将前列腺分为 12 个节段，用于节段性测量粘弹性特性和组织病理学。计算了变异系数（%，CV）以量化异质性。
与良性节段相比，癌性节段的平均组平均值显著增加：|G*|为 12.13kPa 比 6.14kPa，G'为 10.84kPa 比 5.44kPa，G"为 5.45kPa 比 2.92kPa，均 p<0.001。相比之下，良性节段的 CV 显著增加：|G*|为 23.59%比 26.32%（p=0.014），G'为 27.05%比 37.84%（p<0.003），G"为 36.51%比 50.37%（p=0.008）。
PC 的特征是具有僵硬而均匀的生物力学特征，这可能是由于 PC 具有独特的非破坏性生长模式，其中间质提供了受影响区域的刚性支架。相反，良性前列腺节段的异质性增加可能归因于不同前列腺区的存在，这些区域受到特定非恶性病变的影响。
