银屑病皮损部位和严重程度对心理社会残疾及精神病理学的影响。葡萄牙语版SAPASI的观察性研究及心理测量学验证。

Influence of psoriasis lesions' location and severity on psychosocial disability and psychopathology. Observational study and psychometric validation of the SAPASI Portuguese version.

作者信息

Teixeira Ana, Ribeiro Cristiano, Gaio Rita, Torres Tiago, Magina Sofia, Pereira Teresa, Teixeira Maribel, Rocha José Carlos, Lobo José Manuel Sousa, Almeida Isabel Filipa, Vidal Diogo Guedes, Pedrosa E Sousa Hélder Fernando, Dinis Maria Alzira Pimenta, Almeida Vera

机构信息

TOXRUN - Unidade de Investigação em Toxicologia, Instituto Universitário de Ciências da Saúde, CESPU, CRL, 4585-116 Gandra, Portugal; UCIBIO, REQUIMTE, Laboratório de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

Instituto Universitário de Ciências da Saúde, CESPU, CRL, 4585-116 Gandra, Portugal.

出版信息

J Psychosom Res. 2022 Mar;154:110714. doi: 10.1016/j.jpsychores.2021.110714. Epub 2022 Jan 6.

DOI:10.1016/j.jpsychores.2021.110714

PMID:35007943

Abstract

OBJECTIVES

The psychosocial impact of psoriasis is well documented. However, the contributing role of clinical disease characteristics is not satisfactorily explored. This study aimed to validate the Self-administered Psoriasis Area and Severity Index (SAPASI) to a Portuguese population (SAPASI-PT) and to perform its cross-validation, assessing how the results will generalize to an independent data set, with the Psoriasis Area and Severity Index (PASI), in order to assess the influence of psoriasis' severity on psychosocial disability and psychopathology.

METHODS

A cross-sectional study with 228 patients with psoriasis was carried out. Data was collected through a sociodemographic and clinical questionnaire, SAPASI-PT, the Psoriasis Disability Index (PDI) and the Brief Symptoms Inventory (BSI). The cultural and linguistic adaptation of SAPASI to a Portuguese version and the cross validation with PASI was carried out. Multiple associations between psychosocial disability, psychopathology and severity, discomfort and location of lesions were investigated through logistic regression models.

RESULTS

A good adjustment model for SAPASI-PT is found. Also, associations between psychosocial disability, psychopathology and the psoriasis severity and discomfort are found. The existence of lesions is positively associated with the severity of the disease. Patients with lesions in hands or genitals are those reporting a greater discomfort. The presence of lesions in hands is positively associated with PDI, i.e., with leisure and with treatment, marginally. Additionally, patients scoring higher in the personal dimension are found to have a significantly greater percentage of lesions in the genitals.

CONCLUSIONS

The psoriasis severity and location of lesions are important determinants of patients´ quality of life. Lesions on face, hands and genitals are associated with a higher impact on psychosocial wellbeing of patients. Psychological counselling should be considered within psoriasis treatment context in patients with the described disease manifestations.

摘要

目的

银屑病的心理社会影响已有充分记录。然而，临床疾病特征的作用尚未得到充分探讨。本研究旨在验证自我管理的银屑病面积和严重程度指数（Self-administered Psoriasis Area and Severity Index，SAPASI）在葡萄牙人群中的适用性（SAPASI-PT），并进行交叉验证，评估结果如何推广到独立数据集，同时使用银屑病面积和严重程度指数（Psoriasis Area and Severity Index，PASI），以评估银屑病严重程度对心理社会残疾和精神病理学的影响。

方法

对228例银屑病患者进行了横断面研究。通过社会人口统计学和临床问卷、SAPASI-PT、银屑病残疾指数（Psoriasis Disability Index，PDI）和简明症状量表（Brief Symptoms Inventory，BSI）收集数据。对SAPASI进行文化和语言改编以形成葡萄牙语版本，并与PASI进行交叉验证。通过逻辑回归模型研究心理社会残疾、精神病理学与严重程度、不适及皮损部位之间的多重关联。

结果

发现了一个适用于SAPASI-PT的良好调整模型。此外，还发现了心理社会残疾、精神病理学与银屑病严重程度和不适之间的关联。皮损的存在与疾病严重程度呈正相关。手部或生殖器有皮损的患者报告的不适感更强。手部有皮损与PDI呈正相关，即与休闲和治疗有轻微关联。此外，在个人维度得分较高的患者生殖器部位有皮损的比例显著更高。