1,25-二羟基维生素D3与维生素D2之间的相互作用：正常个体中药理剂量的作用

Interactions between 1,25-dihydroxyvitamin D3 and vitamin D2: effects of pharmacologic doses in normal individuals.

作者信息

Hui R, Trube A, Lissner D, Wilkinson M R, Mason R S, Posen S

机构信息

Department of Endocrinology, Royal North Shore Hospital, St. Leonards, NSW, Australia.

出版信息

Clin Pharmacol Ther. 1987 Dec;42(6):641-5. doi: 10.1038/clpt.1987.212.

DOI:10.1038/clpt.1987.212

PMID:3500819

Abstract

To determine whether the administration of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) affects the conversion of a pharmacologic dose of vitamin D2 to 25-hydroxyvitamin D (25OHD), 20 normal subjects received two separate doses of vitamin D2--one with and the other without the concomitant administration of 1,25(OH)2D3. Serum 1,25(OH)2D rose in response to 1,25(OH)2D3 administration and fell when vitamin D2 was given alone. Serum osteocalcin rose in response to 1,25(OH)2D3 administration. Serum 25OHD rose in response to vitamin D2 administration regardless of whether the subjects also received 1,25(OH)2D3. The data from this study in humans support the suggestion that the effects of 1,25(OH)2D3 on serum 25OHD concentrations are mediated through mechanisms other than impairment of production.

摘要

为了确定给予1,25 - 二羟基维生素D3（1,25(OH)2D3）是否会影响药理剂量的维生素D2向25 - 羟基维生素D（25OHD）的转化，20名正常受试者分别接受了两剂维生素D2，一剂同时给予1,25(OH)2D3，另一剂单独给予维生素D2。血清1,25(OH)2D在给予1,25(OH)2D3后升高，而单独给予维生素D2时则下降。血清骨钙素在给予1,25(OH)2D3后升高。无论受试者是否同时接受1,25(OH)2D3，血清25OHD在给予维生素D2后均升高。这项在人体中的研究数据支持了这样的观点，即1,25(OH)2D3对血清25OHD浓度的影响是通过除生产受损之外的其他机制介导的。