Montegut Coline, Correard Florian, Nouguerède Emilie, Rey Dominique, Chevalier Thomas, Meurer Marie, Deville Jean-Laurent, Baciuchka Marjorie, Pradel Vincent, Greillier Laurent, Villani Patrick, Couderc Anne-Laure
Internal Medicine, Geriatrics and Therapeutic Unit, Assistance Publique des Hôpitaux de Marseille (AP-HM), 13009 Marseille, France.
Coordination Unit for Geriatric Oncology (UCOG), PACA West, 13009 Marseille, France.
Cancers (Basel). 2021 Dec 30;14(1):169. doi: 10.3390/cancers14010169.
While comprehensive geriatric assessment (CGA) in older patients treated for cancer assesses several related domains, it does not include standardized biological tests. The present study aimed to: (1) assess the prognosis value of the B12/CRP index (BCI) in a population of systemically treatable older patients with cancer and (2) analyze the association between BCI value and pre-existing geriatric frailty.
We conducted a retrospective observational study between January 2016 and June 2020 at Marseille University Hospital. All consecutive cancer patients aged 70 years and over before initiating systemic therapy were included.
Of the 863 patients included, 60.5% were men and 42.5% had metastatic stage cancer. Mean age was 81 years. The low-BCI group (≤10,000) had a significantly longer survival time than the mid-BCI (10,000 < BCI ≤ 40,000) and high-BCI (BCI > 40,000) groups (HR = 0.327, CI95% [0.26-0.42], -value = 0.0001). Mid- and high-BCI (BCI > 40,000) values were associated with impaired functional status and malnutrition.
A BCI > 10,000 would appear to be a good biological prognostic factor for poor survival times and pre-existing geriatric impairment in older cancer patients before they initiate systemic treatment.
虽然对接受癌症治疗的老年患者进行的综合老年评估（CGA）评估了几个相关领域，但它不包括标准化的生物学检测。本研究旨在：（1）评估B12/CRP指数（BCI）在可进行全身治疗的老年癌症患者群体中的预后价值，以及（2）分析BCI值与已存在的老年衰弱之间的关联。
我们于2016年1月至2020年6月在马赛大学医院进行了一项回顾性观察研究。纳入所有在开始全身治疗前年龄在70岁及以上的连续癌症患者。
在纳入的863例患者中，60.5%为男性，42.5%患有转移性癌症。平均年龄为81岁。低BCI组（≤10,000）的生存时间明显长于中BCI组（10,000 < BCI ≤ 40,000）和高BCI组（BCI > 40,000）（HR = 0.327，95%CI [0.26 - 0.42]，P值 = 0.0001）。中BCI和高BCI（BCI > 40,000）值与功能状态受损和营养不良相关。
BCI > 10,000似乎是老年癌症患者在开始全身治疗前生存时间不佳和已存在老年功能损害的良好生物学预后因素。
