Oba T, Hotta K
Department of Physiology, Nagoya City University Medical School, Japan.
Eur J Pharmacol. 1987 Nov 10;143(2):275-8. doi: 10.1016/0014-2999(87)90543-7.
To determine the mechanism by which Ag+ induces a transient contracture in skeletal muscle, the effect of dantrolene sodium on the Ag+ contracture was examined and the findings compared with those for the twitch, tetanus and caffeine contracture. The inhibition of twitch by dantrolene was equivalent to that of the Ag+ contracture at concentrations of 1, 2 or 5 microM of dantrolene. The tetanus tension was slightly inhibited by dantrolene, but not the caffeine contracture. These observations suggest that the Ag+ contracture may be governed by the same mechanism as that involved in the development of twitch tension.
为确定银离子（Ag⁺）诱导骨骼肌产生短暂挛缩的机制，研究了丹曲林钠对Ag⁺挛缩的影响，并将结果与对单收缩、强直收缩和咖啡因挛缩的研究结果进行比较。在丹曲林浓度为1、2或5微摩尔时，丹曲林对单收缩的抑制作用与对Ag⁺挛缩的抑制作用相当。丹曲林对强直收缩张力有轻微抑制作用，但对咖啡因挛缩无抑制作用。这些观察结果表明，Ag⁺挛缩可能与单收缩张力产生所涉及的机制相同。
