泛素和类泛素蛋白修饰的急性髓系白血病相关蛋白。

Department of Biomedical Science, CHA University, Seongnam-si 13488, Gyeonggi-do, Korea.

Int J Mol Sci. 2022 Jan 3;23(1):514. doi: 10.3390/ijms23010514.

Acute myeloid leukemia (AML), the most common form of an acute leukemia, is a malignant disorder of stem cell precursors of the myeloid lineage. Ubiquitination is one of the post-translational modifications (PTMs), and the ubiquitin-like proteins (Ubls; SUMO, NEDD8, and ISG15) play a critical role in various cellular processes, including autophagy, cell-cycle control, DNA repair, signal transduction, and transcription. Also, the importance of Ubls in AML is increasing, with the growing research defining the effect of Ubls in AML. Numerous studies have actively reported that AML-related mutated proteins are linked to Ub and Ubls. The current review discusses the roles of proteins associated with protein ubiquitination, modifications by Ubls in AML, and substrates that can be applied for therapeutic targets in AML.

急性髓细胞白血病（AML）是急性白血病中最常见的一种形式，是髓系前体细胞的恶性疾病。泛素化是一种翻译后修饰（PTM），泛素样蛋白（Ubl；SUMO、NEDD8 和 ISG15）在包括自噬、细胞周期控制、DNA 修复、信号转导和转录在内的各种细胞过程中发挥关键作用。此外，Ubl 在 AML 中的重要性正在增加，越来越多的研究定义了 Ubl 在 AML 中的作用。大量研究积极报道 AML 相关突变蛋白与 Ub 和 Ubls 有关。本综述讨论了与蛋白质泛素化相关的蛋白质、Ubl 在 AML 中的修饰作用以及可作为 AML 治疗靶点的底物的作用。