Singer R, Segenreich E, Sagiv M, Shohat B, Livni E, Bartoov B, Zukerman Z, Leiba S, Servadio C
Male Fertility Laboratory, Beilinson Medical Centre, Petah Tikva, Israel.
Int J Androl. 1987 Oct;10(5):685-9. doi: 10.1111/j.1365-2605.1987.tb00370.x.
A 33-year-old male of proven fertility suffered six attacks of malaria while resident in an African country. For this he received anti-malarial drugs. Semen analysis performed after the fourth attack, and repeated during the following 2 years after his return to Israel, revealed severe oligozoospermia, necrozoospermia and occasionally even azoospermia. Immunological examination of the patient revealed an inverse ratio of T-cell subsets and mast cell degranulation in response to palludrin. Twenty-five months after the last attack of malaria a significant improvement was found in semen quality and there was an increase in the ratio of T-helper to T-suppressor cytotoxic cells. These observations indicate that although malaria and its treatment may affect spermatogenesis, recovery may be expected eventually.
一名经证实有生育能力的33岁男性在非洲国家居住期间患了6次疟疾。为此他接受了抗疟药物治疗。在第四次发作后进行了精液分析，并在他返回以色列后的接下来2年里重复进行，结果显示严重少精子症、死精子症，偶尔甚至无精子症。对该患者的免疫学检查发现T细胞亚群比例倒置以及对氯喹反应的肥大细胞脱颗粒。在最后一次疟疾发作25个月后，精液质量有了显著改善，辅助性T细胞与抑制性细胞毒性T细胞的比例增加。这些观察结果表明，尽管疟疾及其治疗可能影响精子发生，但最终有望恢复。
