Bruce R A, Fisher L D
Department of Medicine, University of Washington, Seattle 98195.
J Electrocardiol. 1987 Oct;20 Suppl:162-6.
Exercise-enhanced risk assessment for subsequent morbidity and mortality due to coronary heart disease in 4105 asymptomatic healthy men (mean age of 44.6 +/- 7.9 years) is reported for in Seattle community practice. Annual incidence of primary coronary events ranges from 0.22% in 1792 men (43.6%) without conventional risk factors, to 0.42% in the majority of men (55.3%) with any risk factor(s) and less than two abnormal responses to maximal exercise. Among 44 men (1.1%) at high risk defined by any conventional risk factor(s) and any two or more abnormal responses to maximal exercise, annual incidence of primary coronary events is 5.2% (P less than 0.001). Of 1718 men under 60 years of age without conventional risk factors, 117 or 6.8% who developed ischemic ST depression with maximal exercise testing are false positive responders since no coronary event occurred during the next five years.
西雅图社区实践报告了对4105名无症状健康男性（平均年龄44.6±7.9岁）进行运动增强的冠心病后续发病和死亡风险评估情况。原发性冠状动脉事件的年发病率在无传统危险因素的1792名男性（43.6%）中为0.22%，在有任何危险因素且对最大运动测试异常反应少于两项的大多数男性（55.3%）中为0.42%。在由任何传统危险因素以及对最大运动测试有任何两项或更多异常反应所定义的44名高危男性（1.1%）中，原发性冠状动脉事件的年发病率为5.2%（P<0.001）。在1718名60岁以下无传统危险因素的男性中，117名（6.8%）在最大运动测试时出现缺血性ST段压低，这些是假阳性反应者，因为在接下来五年中未发生冠状动脉事件。
