Donnan G A, Kaczmarczyk S J, McKenzie J S, Rowe P J, Kalnins R M, Mendelsohn F A
Department of Neurology, Austin Hospital, University of Melbourne, Australia.
J Neurol Sci. 1987 Nov;81(2-3):261-71. doi: 10.1016/0022-510x(87)90101-8.
When the regional effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on brain dopamine uptake sites in C57 Black mice were studied using [3H]mazindol autoradiography, marked regional differences in effect were seen: the mesolimbic system was less affected than the nigrostriatal tract and within each system the effect was more severe in the terminal fields of the striatum than in the cells of origin. Within the striatum itself there was inhomogeneity of effect, with relative sparing of the dorsomedial aspect compared to the remainder. Complete recovery of [3H]mazindol binding to striatal membranes occurred over 12 months, while dopamine levels recovered more slowly. This supports the concept that MPTP has a highly selective effect within dopaminergic systems and that the initial effect is more pronounced on distal terminals compared to cell bodies. The possibility that recovery of mazindol binding with time may be associated with terminal regrowth needs to be investigated further.
当使用[3H]麦角腈放射自显影术研究1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）对C57黑小鼠脑多巴胺摄取位点的区域效应时，观察到明显的区域效应差异：中脑边缘系统受影响程度小于黑质纹状体束，并且在每个系统中，纹状体终末场的效应比起源细胞更严重。在纹状体内，效应存在不均匀性，与其余部分相比，背内侧部分相对未受影响。[3H]麦角腈与纹状体膜的结合在12个月内完全恢复，而多巴胺水平恢复得更慢。这支持了MPTP在多巴胺能系统内具有高度选择性作用的概念，并且与细胞体相比，初始效应在远端终末更明显。麦角腈结合随时间恢复可能与终末再生相关的可能性需要进一步研究。
