下颌下唾液腺对小鼠乳腺激素反应性的影响。

Influence of submandibular salivary glands on hormone responsiveness of mouse mammary glands.

作者信息

Sheffield L G, Welsch C W

机构信息

Dairy Science Department, University of Wisconsin, Madison 53706.

出版信息

Proc Soc Exp Biol Med. 1987 Dec;186(3):368-77. doi: 10.3181/00379727-186-42627.

DOI:10.3181/00379727-186-42627

PMID:3501124

Abstract

Surgical removal of the submandibular salivary glands (sialoadenectomy) of female Balb/c mice significantly (P less than 0.05) reduced mammary development as judged by development scores and mammae DNA levels. Reduction in mammae development score by sialoadenectomy was observed in both mice saline injected and mice treated with estradiol and progesterone. Autografts of submandibular salivary tissue or daily administration of EGF to sialoadenectomized mice partly alleviated the atrophy of the mammary gland induced by sialoadenectomy (P less than 0.05). The results of our studies are consistent with a model of mammary gland developmental regulation that includes the submandibular salivary gland as a mediator of mammogenesis via secretion of EGF.

摘要

通过手术切除雌性Balb/c小鼠的下颌下唾液腺（唾液腺切除术），以发育评分和乳腺DNA水平判断，乳腺发育显著（P<0.05）受到抑制。在注射生理盐水的小鼠以及用雌二醇和孕酮处理的小鼠中，均观察到唾液腺切除术导致乳腺发育评分降低。将下颌下唾液组织自体移植或对唾液腺切除的小鼠每日给予表皮生长因子（EGF），可部分缓解唾液腺切除术诱导的乳腺萎缩（P<0.05）。我们的研究结果与一种乳腺发育调控模型一致，该模型认为下颌下唾液腺通过分泌EGF作为乳腺生成的介质。