Yoshino Aya, Nakamura Yoshihiko, Irie Yuhei, Kitamura Taisuke, Takata Tohru, Ishikura Hiroyasu, Kondo Seiji
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Department of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
J Clin Med. 2021 Dec 23;11(1):42. doi: 10.3390/jcm11010042.
The oral health of coronavirus disease 2019 (COVID-19) patients in the intensive care unit (ICU) is an important issue in treatment of respiratory failure. We retrospectively investigated the oral health history of severe COVID-19 patients who received extracorporeal membrane oxygenation (ECMO) from April 2020 to December 2020 using the oral assessment guide from Fukuoka University (OAG-F). Nineteen consecutive patients (median age: 62 years) were divided into two groups according to survival (survivors, = 12; non-survivors, = 7). A univariate analysis revealed no significant differences between the groups in sex, age, body mass index (BMI), or the number of remaining teeth, whereas the ECMO assistance of non-survivors (median: 34 days) was prolonged in comparison to survivors (median: 8 days; < 0.05). Among the factors of OAG-F, significant differences were observed between the groups in the conditions of the saliva, mucous membrane, and gingiva. The total scores in non-survivors (median: 19) were significantly higher in comparison to survivors (Median: 15.5), suggesting that the frequency of oral health deterioration was higher in non-survivors ( 0.05). Taken together, these findings suggest that poor oral health is associated with mortality in COVID-19 patients receiving ECMO in the ICU.
重症监护病房（ICU）中2019冠状病毒病（COVID-19）患者的口腔健康是呼吸衰竭治疗中的一个重要问题。我们使用福冈大学口腔评估指南（OAG-F），回顾性调查了2020年4月至2020年12月期间接受体外膜肺氧合（ECMO）治疗的重症COVID-19患者的口腔健康史。连续19例患者（中位年龄：62岁）根据生存情况分为两组（幸存者，n = 12；非幸存者，n = 7）。单因素分析显示，两组在性别、年龄、体重指数（BMI）或剩余牙齿数量方面无显著差异，而非幸存者的ECMO辅助时间（中位值：34天）比幸存者（中位值：8天）延长（P < 0.05）。在OAG-F的各项因素中，两组在唾液、黏膜和牙龈状况方面存在显著差异。非幸存者的总评分（中位值：19分）显著高于幸存者（中位值：15.5分），表明非幸存者口腔健康恶化的频率更高（P < 0.05）。综上所述，这些发现表明，口腔健康状况不佳与ICU中接受ECMO治疗的COVID-19患者的死亡率相关。
