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J Clin Med. 2021 Dec 26;11(1):110. doi: 10.3390/jcm11010110.
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Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section.用于预防剖宫产术接受区域麻醉的女性恶心和呕吐的干预措施。
Cochrane Database Syst Rev. 2021 May 18;5(5):CD007579. doi: 10.1002/14651858.CD007579.pub3.
2
Patients' self-reported nausea: Validation of the Numerical Rating Scale and of a daily summary of repeated Numerical Rating Scale scores.患者自述恶心：数字评定量表和重复数字评定量表评分每日摘要的验证。
J Clin Nurs. 2019 Mar;28(5-6):959-968. doi: 10.1111/jocn.14705. Epub 2018 Nov 8.
3
Techniques for preventing hypotension during spinal anaesthesia for caesarean section.剖宫产脊髓麻醉期间预防低血压的技术。
Cochrane Database Syst Rev. 2017 Aug 4;8(8):CD002251. doi: 10.1002/14651858.CD002251.pub3.
4
6% Hydroxyethyl starch (130/0.4) vs Ringer's lactate preloading before spinal anaesthesia for Caesarean delivery: the randomized, double-blind, multicentre CAESAR trial.剖宫产脊髓麻醉前6%羟乙基淀粉（130/0.4）与乳酸林格氏液预负荷的比较：随机、双盲、多中心CAESAR试验
Br J Anaesth. 2014 Sep;113(3):459-67. doi: 10.1093/bja/aeu103. Epub 2014 Jun 26.
5
Interventions at caesarean section for reducing the risk of aspiration pneumonitis.剖宫产术中降低误吸性肺炎风险的干预措施。
Cochrane Database Syst Rev. 2014 Feb 5;2014(2):CD004943. doi: 10.1002/14651858.CD004943.pub4.
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Intraoperative oxygen administration does not reduce the incidence or severity of nausea or vomiting associated with neuraxial anesthesia for cesarean delivery.剖宫产术中给予氧气并不能降低与蛛网膜下腔麻醉相关的恶心或呕吐的发生率或严重程度。
Anesth Analg. 2007 Oct;105(4):1113-7, table of contents. doi: 10.1213/01.ane.0000278626.54116.0e.
7
Pharmacokinetics of midazolam, propofol, and fentanyl transfer to human breast milk.咪达唑仑、丙泊酚和芬太尼向人母乳转移的药代动力学。
Clin Pharmacol Ther. 2006 Jun;79(6):549-57. doi: 10.1016/j.clpt.2006.02.010.
8
Intraoperative nausea and vomiting during cesarean section under regional anesthesia.区域麻醉下剖宫产术中的恶心呕吐
Int J Obstet Anesth. 2005 Jul;14(3):230-41. doi: 10.1016/j.ijoa.2004.12.004.
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Effect of postoperative supplemental oxygen on nausea and vomiting after cesarean birth.剖宫产术后补充氧气对恶心和呕吐的影响。
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甲氧氯普胺与丙泊酚预防脊髓麻醉下剖宫产术中恶心呕吐的随机、安慰剂对照、双盲试验

Metoclopramide and Propofol to Prevent Nausea and Vomiting during Cesarean Section under Spinal Anesthesia: A Randomized, Placebo-Controlled, Double-Blind Trial.

作者信息

Mokini Zhirajr, Genocchio Valentina, Forget Patrice, Petrini Flavia

机构信息

Independent Researcher, European Society of Anaesthesiology and Intensive Care Mentorship Programme, B-1000 Brussels, Belgium.

Ospedale San Maurizio di Bolzano, Via Lorenz Böhler 5, 39100 Bolzano, Italy.

出版信息

J Clin Med. 2021 Dec 26;11(1):110. doi: 10.3390/jcm11010110.

DOI:10.3390/jcm11010110
PMID:35011852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8745529/
Abstract

BACKGROUND

Intra-operative nausea, vomiting and retching (NVR) are frequently associated with subarachnoid anesthesia (SA) in women undergoing cesarean section (CS). In this study performed in women undergoing CS under SA with a risk factor control strategy, we compared saline (placebo), propofol, metoclopramide and both drugs to prevent NVR.

METHODS

We recorded NVR events in 110 women undergoing CS who were randomized after umbilical cord clamping to receive saline (S; = 27), metoclopramide 10 mg (M; = 28), propofol 1 mg/kg/h (P; = 27) or both drugs (PM; = 28).

RESULTS

The proportion of women with intra-operative nausea was: S: 17/27 (63%); P: 15/27 (56%); M: 13/28 (46%); PM: 6/28 (21%) ( = 0.012, Cramér's V = 0.31 (large effect). The proportion of women with intra-operative vomiting/retching was: S: 9/27 (33%); M: 7/27 (25%); P: 3/28 (11%); PM 2/28 (7%) ( = 0.049, Cramér's V = 0.26 (medium effect). Post-hoc multiple comparisons revealed a significant reduction in NVR episodes and NRS scores between the PM group and control. Sedation scores did not differ among groups.

CONCLUSION

In women undergoing CS under SA with a risk factor control strategy, combined propofol and metoclopramide reduce nausea and vomiting.

摘要

背景

剖宫产（CS）术中恶心、呕吐和干呕（NVR）常与蛛网膜下腔麻醉（SA）相关。在本项针对有危险因素控制策略的接受SA的CS女性进行的研究中，我们比较了生理盐水（安慰剂）、丙泊酚、甲氧氯普胺以及两种药物联合使用对NVR的预防作用。

方法

我们记录了110例接受CS的女性的NVR事件，这些女性在脐带夹闭后被随机分组，分别接受生理盐水（S组；n = 27）、10 mg甲氧氯普胺（M组；n = 28）、1 mg/kg/h丙泊酚（P组；n = 27）或两种药物联合使用（PM组；n = 28）。

结果

术中出现恶心的女性比例为：S组：17/27（63%）；P组：15/27（56%）；M组：13/28（46%）；PM组：6/28（21%）（P = 0.012，克莱默V系数 = 0.31（强效））。术中出现呕吐/干呕的女性比例为：S组：9/27（33%）；M组：7/27（25%）；P组：3/28（11%）；PM组：2/28（7%）（P = 0.049，克莱默V系数 = 0.26（中效））。事后多重比较显示，PM组与对照组相比，NVR发作次数和数字评分量表（NRS）评分显著降低。各组间镇静评分无差异。

结论

在有危险因素控制策略的接受SA的CS女性中，丙泊酚与甲氧氯普胺联合使用可减少恶心和呕吐。