Cobianchi Bellisari Flavia, Palumbo Pierpaolo, Masciocchi Carlo, Zoccali Carmine, Barile Antonio, Arrigoni Francesco
Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Abruzzo Health Unit 1, Department of Diagnostic Imaging, Area of Cardiovascular and Interventional Imaging, 67100 L'Aquila, Italy.
J Clin Med. 2021 Dec 27;11(1):128. doi: 10.3390/jcm11010128.
Osteoblastoma (OB) and osteoid osteoma (OO) are benign bone-forming tumors, with nearly identical basic microscopic features. The main difference is dimension (OO has usually a nidus measuring <2 cm in diameter). In addition, OB is biologically more active than OO, with a tendency to grow in size. Historically, treatments have included surgical resection and analgesics, although invasiveness and poor tolerance have led to the current standard of care moving toward interventional radiology, where radiofrequency ablation (RFA) represents the most diffuse technique. Magnetic resonance-guided focused ultrasound surgery (MRgFUS) has recently emerged as another innovative alternative treatment, providing tumor ablation through a needleless and ionizing radiation-free modality. In addition, this technique has the ability to guarantee a very precise and controlled increase in temperature, delivering small amounts of energy that can accurately destroy only the lesion, avoiding healthy surrounding tissues. The present review focuses on MRgFUS as the less invasive, safe, effective, and durable treatment option for the management of osteoid osteoma and osteoblastoma, including a description of technical details, indications and outcomes.
骨母细胞瘤（OB）和骨样骨瘤（OO）是良性成骨肿瘤，具有几乎相同的基本微观特征。主要区别在于尺寸（骨样骨瘤通常有一个直径<2 cm的瘤巢）。此外，骨母细胞瘤在生物学上比骨样骨瘤更活跃，有增大的趋势。从历史上看，治疗方法包括手术切除和使用镇痛药，尽管侵入性和耐受性差导致目前的护理标准转向介入放射学，其中射频消融（RFA）是最常用的技术。磁共振引导聚焦超声手术（MRgFUS）最近已成为另一种创新的替代治疗方法，通过无针和无电离辐射的方式实现肿瘤消融。此外，该技术能够保证非常精确和可控的温度升高，传递少量能量，仅能精确破坏病变，避免周围健康组织。本综述重点关注MRgFUS作为治疗骨样骨瘤和骨母细胞瘤的侵入性较小、安全、有效且持久的治疗选择，包括技术细节、适应症和治疗结果的描述。
