Colombini Alessandra, Lombardo Michele Davide Maria, de Girolamo Laura, De Vecchi Elena, Giorgino Riccardo, Peretti Giuseppe Maria, Banfi Giuseppe, Mangiavini Laura
Laboratorio di Biotecnologie Applicate all'Ortopedia, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.
Residency Program in Orthopedics and Traumatology, University of Milan, 20122 Milan, Italy.
J Clin Med. 2021 Dec 29;11(1):168. doi: 10.3390/jcm11010168.
The coronavirus disease 2019 (COVID-19) pandemic outbreak has posed new problems in the context of patients suffering from other diseases. In particular, musculoskeletal sequelae related to the state of debilitation associated with COVID-19 are important to consider in elderly patients undergoing surgery after lower limbs fracture, especially in the post-operative period. The objective of this study was to evaluate whether COVID-19 influenced biochemical parameter, recovery and mortality of surgically treated patients suffering from lower extremity fractures.
Laboratory and clinical data of 30 patients were extrapolated and analyzed in the pre-operative and post-operative periods. Among these patients, 13 had COVID-19 infection (COVID-19 +), whereas 17 had no signs of COVID-19 infections (COVID-19 -). Long-term clinical and functional outcomes were also analyzed.
Lower calcium, slightly higher values of CRP and much higher values of CPK and AST were observed pre-operatively in COVID-19 + patients, who also showed higher prevalence of long-term sequelae than COVID-19 - patients.
COVID-19 affects long-term outcome of elderly patients with lower limb fractures in a multifactorial way. First, the virus directly damages the muscle tissue. Secondly, the lung function impairment worsens the overall performance, making rehabilitation more challenging.
2019年冠状病毒病（COVID-19）大流行在患有其他疾病的患者背景下带来了新问题。特别是，与COVID-19相关的衰弱状态引起的肌肉骨骼后遗症，对于下肢骨折后接受手术的老年患者，尤其是术后阶段，是需要考虑的重要因素。本研究的目的是评估COVID-19是否影响接受手术治疗的下肢骨折患者的生化参数、恢复情况和死亡率。
对30例患者术前和术后的实验室及临床数据进行了推断和分析。在这些患者中，13例感染了COVID-19（COVID-19 +），而17例没有COVID-19感染迹象（COVID-19 -）。还分析了长期的临床和功能结局。
COVID-19 +患者术前观察到血钙较低、CRP值略高、CPK和AST值高得多，并且与COVID-19 -患者相比，其长期后遗症的患病率也更高。
COVID-19以多因素方式影响老年下肢骨折患者的长期结局。首先，病毒直接损害肌肉组织。其次，肺功能损害使整体状况恶化，使康复更具挑战性。
