Wessel G, Abendroth K
Klinik und Poliklinik für Innere Medizin, Friedrich-Schiller-Universität Jena.
Z Gesamte Inn Med. 1987 Oct 1;42(19):533-6.
From the demonstration of etiopathogenetic mechanisms of osteopenia 7 different histologically and histomorphometrically defined pictures of the state (diseases) of the skeleton are derived. From this 4 different possibilities of the influence on the permanent transformation of the skeleton--the remodeling are the result. The medicamentous support of the blockade or stimulation of osteoclasts and the optimization of the mineralization are the basis of therapeutic considerations. In the light of these pathogenetically orientated treatment strategies the real and at present practicable therapy regimes of the various clinical manifestations of the osteopenia and new beginnings especially also of the therapy of osteoporosis are discussed.
从骨质减少的病因发病机制的论证中，得出了7种在组织学和组织形态计量学上定义的骨骼状态（疾病）的不同图像。由此产生了对骨骼永久性转变——重塑的4种不同影响可能性。对破骨细胞的阻断或刺激以及矿化优化的药物支持是治疗考虑的基础。根据这些以发病机制为导向的治疗策略，讨论了骨质减少各种临床表现的实际且目前可行的治疗方案，尤其是骨质疏松症治疗的新开端。
