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[牙髓病治疗中活髓治疗与牙髓再生的新进展:从基础到临床应用]

[New advances in vital pulp therapy and pulp regeneration for the treatment of pulpitis: from basic to clinical application].

作者信息

He W X, Yu Q

机构信息

Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University & State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Xi'an 710032, China.

出版信息

Zhonghua Kou Qiang Yi Xue Za Zhi. 2022 Jan 9;57(1):16-22. doi: 10.3760/cma.j.cn112144-20210917-00417.

Abstract

In recent years, great progress has been made in research on the treatment of pulpitis, mainly due to the rapid development of basic and clinical researches in this field, and some achievement from basic research has been applied in clinical practice. Advances in the diagnostic methods for pulpitis can help the clinicians to recognize the true state of pulpitis more accurately and to adopt the corresponding treatment methods including indirect/direct pulp capping, pulpotomy, pulp regeneration and root canal therapy. The new theory of pulpitis diagnosis and the studies on immune defense, repair function of dental pulp and new pulp capping materials have significantly improved the success rate of vital pulp therapy. For diffuse coronary pulpitis or radicular pulpitis, which is difficult to achieve vital pulp therapy successfully, methods of pulp revascularization, cell homing and pulp stem cells-mediated pulp regeneration can also be used as treatment options in addition to root canal therapy. The present article focuses on the research progress on pulpitis treatments and related clinical transformation practices, in order to provide reference on vital pulp therapy and pulp regeneration for clinicians.

摘要

近年来,牙髓炎治疗研究取得了巨大进展,这主要得益于该领域基础研究和临床研究的快速发展,并且基础研究的一些成果已应用于临床实践。牙髓炎诊断方法的进步有助于临床医生更准确地认识牙髓炎的真实状况,并采取相应的治疗方法,包括间接/直接盖髓术、牙髓切断术、牙髓再生和根管治疗。牙髓炎诊断的新理论以及牙髓免疫防御、修复功能和新型盖髓材料的研究显著提高了活髓治疗的成功率。对于难以成功实现活髓治疗的弥漫性冠髓炎或根髓炎,除根管治疗外,牙髓血管再生、细胞归巢和牙髓干细胞介导的牙髓再生方法也可作为治疗选择。本文重点关注牙髓炎治疗的研究进展及相关临床转化实践,旨在为临床医生在活髓治疗和牙髓再生方面提供参考。

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