Division of Orthodontics, University of Connecticut Health Center, Farmington, Conn.
Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, Conn.
Am J Orthod Dentofacial Orthop. 2022 May;161(5):687-697.e3. doi: 10.1016/j.ajodo.2020.10.033. Epub 2022 Jan 7.
Vitamin E is a popular antioxidant suggested to affect bone turnover. However, the effects of a vitamin E enriched diet on the rate of tooth movement are unknown. Therefore, this study aimed to evaluate tooth movement in rats receiving a vitamin E enriched diet. In addition, we examined bone remodeling in experimental and control rats.
Thirty-two 6-week-old male rats were divided into 4 groups: (1) group 1 (n = 8): orthodontic tooth movement (OTM) for 4 days + regular diet; (2) group 2 (n = 8): OTM for 14 days + regular diet; (3) group 3 (n = 8): OTM for 4 days + vitamin E diet; and (4) group 4 (n = 8) - OTM for 14 days + vitamin E diet. Maxillary alveolar bones and femurs of rats were analyzed by microcomputed tomography and histology.
Rats fed a vitamin E diet presented an increased OTM rate at days 4 and 14. We found an increased number of osteoclasts and decreased bone volume in the vitamin E diet group at day 14 of OTM. In addition, there was increased expression of the microphthalmia-associated transcription factor in the alveolar bone of the vitamin E diet group. In contrast, there was no difference in bone remodeling in femurs or alveolar bone at the control side.
We found that an enriched vitamin E diet increases the rate of OTM in rats, suggesting that vitamin E may be useful as an avenue to accelerate OTM.
维生素 E 是一种常用的抗氧化剂，据称可影响骨转换。然而，富含维生素 E 的饮食对牙齿移动速度的影响尚不清楚。因此，本研究旨在评估接受富含维生素 E 的饮食的大鼠的牙齿移动情况。此外，我们还研究了实验组和对照组大鼠的骨重建情况。
32 只 6 周龄雄性大鼠分为 4 组：（1）组 1（n=8）：正畸牙齿移动（OTM）4 天+常规饮食；（2）组 2（n=8）：OTM 14 天+常规饮食；（3）组 3（n=8）：OTM 4 天+维生素 E 饮食；（4）组 4（n=8）：OTM 14 天+维生素 E 饮食。通过微计算机断层扫描和组织学分析大鼠的上颌牙槽骨和股骨。
喂食维生素 E 饮食的大鼠在第 4 天和第 14 天的 OTM 速度增加。我们发现，在 OTM 第 14 天，维生素 E 饮食组的破骨细胞数量增加，骨量减少。此外，维生素 E 饮食组牙槽骨中的小眼相关转录因子表达增加。相反，在对照组的股骨或牙槽骨中，骨重建没有差异。
我们发现富含维生素 E 的饮食可增加大鼠的 OTM 速度，表明维生素 E 可能有助于加速 OTM。
