Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine.
Department of Nephrology and Kidney Center, Kakogawa Central City Hospital.
J Atheroscler Thromb. 2022 Nov 1;29(11):1646-1654. doi: 10.5551/jat.63265. Epub 2022 Jan 9.
Acute kidney injury (AKI) is an important clinical issue in the diagnosis and treatment of cardiovascular diseases. The association between pretreatment by statins and the occurrence of AKI in patients with peripheral arterial diseases (PAD) remains unclear. Therefore, we examined the association between statin therapy and the occurrence of AKI in patients with PAD.
We retrospectively analyzed data from the endovascular treatment (EVT) database in our hospital. A total of 295 patients who underwent angiography and/or intervention for PAD between October 2011 and March 2016 were enrolled and divided into two groups: those without statins (control group; N=157) and those with statins (statin group; N=138) for at least 1 month before admission. We examined the occurrence of AKI and its related factors in these patients.
The serum creatinine levels, dose of contrast medium, use of a renin-angiotensin system inhibitor, smoking habit, and blood pressure were similar in both groups. The statin group had more diabetes patients, had patients who were significantly younger, had patients with a higher body mass index (BMI), and had patients with lower low-density lipoprotein cholesterol than the control group. With regard to the occurrence of AKI, there was a significantly lower incidence in the statin group compared with the control group (5% vs. 16%, p＜0.05). The result of the multivariate analysis indicated that statin therapy was significantly correlated with lower occurrence rates of AKI (p＜0.05).
Our study suggests that statin therapy might prevent the occurrence of AKI after angiography and/or intervention for PAD.
急性肾损伤（AKI）是心血管疾病诊断和治疗中的一个重要临床问题。在周围动脉疾病（PAD）患者中，他汀类药物预处理与 AKI 发生之间的关系尚不清楚。因此，我们研究了 PAD 患者他汀类药物治疗与 AKI 发生之间的关系。
我们回顾性分析了我院血管内治疗（EVT）数据库中的数据。共纳入 295 例 2011 年 10 月至 2016 年 3 月期间因 PAD 行血管造影和/或介入治疗的患者，分为两组：未使用他汀类药物的患者（对照组；n=157）和至少在入院前 1 个月开始使用他汀类药物的患者（他汀组；n=138）。我们检查了这些患者 AKI 的发生及其相关因素。
两组患者的血清肌酐水平、造影剂剂量、肾素-血管紧张素系统抑制剂的使用、吸烟习惯和血压相似。他汀组的糖尿病患者更多，患者年龄明显更小，体重指数（BMI）更高，低密度脂蛋白胆固醇水平更低。在 AKI 的发生方面，他汀组的发生率明显低于对照组（5% vs. 16%，p＜0.05）。多变量分析结果表明，他汀类药物治疗与 AKI 发生率降低显著相关（p＜0.05）。
我们的研究表明，他汀类药物治疗可能预防 PAD 血管造影和/或介入治疗后 AKI 的发生。
