Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, 17177, Stockholm, Sweden.
Unit of Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Sci Rep. 2022 Jan 10;12(1):409. doi: 10.1038/s41598-021-04515-x.
We conducted a Mendelian randomization study to determine the associations of body mass index (BMI), type 2 diabetes (T2D), systolic blood pressure (SBP), coffee and alcohol consumption and smoking initiation with senile cataract. Independent single nucleotide polymorphisms associated with the metabolic and lifestyle factors at the p < 5 × 10 were selected as instrument variables. Summary-level data for senile cataract were obtained from the FinnGen consortium (20,157 cases and 154,905 non-cases) and UK Biobank study (6332 cases and 354,862 non-cases). Higher genetically predicted BMI and SBP and genetic predisposition to T2D and smoking initiation were associated with an increased risk of senile cataract. The combined odds ratios were 1.19 (95% confidence interval (CI) 1.09-1.29; p < 0.001) per one standard deviation increase in BMI (~ 4.8 kg/m), 1.13 (95% CI 1.04-1.23; p = 0.004) per 10 mmHg increase in SBP, 1.06 (95% CI 1.03-1.09; p < 0.001) per one unit increase in log-transformed odds ratio of T2D, and 1.19 (95% CI 1.10-1.29; p < 0.001) per one standard deviation increase in prevalence of smoking initiation. Genetically predicted coffee consumption showed a suggestive association with senile cataract (odds ratio per 50% increase, 1.18, 95% CI 1.00-1.40; p = 0.050). This study suggests causal roles of obesity, T2D, SBP and smoking in senile cataract.
我们进行了一项孟德尔随机化研究，以确定体重指数（BMI）、2 型糖尿病（T2D）、收缩压（SBP）、咖啡和酒精摄入以及吸烟起始与老年性白内障之间的关联。选择与代谢和生活方式因素相关的独立单核苷酸多态性作为工具变量，其在 p < 5 × 10 时有统计学意义。老年性白内障的汇总水平数据来自 FinnGen 联盟（20157 例病例和 154905 例非病例）和英国生物库研究（6332 例病例和 354862 例非病例）。较高的遗传预测 BMI 和 SBP，以及 T2D 和吸烟起始的遗传易感性与老年性白内障风险增加相关。合并比值比分别为 BMI 每增加一个标准差（约 4.8 kg/m）为 1.19（95%置信区间（CI）1.09-1.29；p < 0.001），SBP 每增加 10 mmHg 为 1.13（95% CI 1.04-1.23；p = 0.004），T2D 的对数转换比值比每增加一个单位为 1.06（95% CI 1.03-1.09；p < 0.001），吸烟起始流行率每增加一个标准差为 1.19（95% CI 1.10-1.29；p < 0.001）。遗传预测的咖啡摄入量与老年性白内障呈显著相关（每增加 50%的比值比为 1.18，95% CI 1.00-1.40；p = 0.050）。本研究提示肥胖、T2D、SBP 和吸烟与老年性白内障之间存在因果关系。
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