Lin Lixia, Liang Yongshun, Jiang Guiyang, Gan Qingqiao, Yang Tianqi, Liao Peipei, Liang Hao
Ophthalmology Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, GuangXi, China.
Ophthalmology Department, The First People's Hospital of Nanning, Nanning, Guangxi, China.
PLoS One. 2025 Jun 23;20(6):e0326263. doi: 10.1371/journal.pone.0326263. eCollection 2025.
Cataract is the most prevalent cause of blindness. Surgery remains the only effective and widely accepted treatment; early diagnosis and intervention can significantly prevent blindness. Hence,Understanding the current epidemiological status of cataract is crucial for formulating better healthcare policies and effectively preventing blindness due to cataract.
This study utilizes Global burden of Disease (GBD) 2021 data to conduct an in-depth analysis of the burden of cataract from 1990 to 2021, including gender disparities, risk factors, and the relationship between Socio-Demographic index (SDI) and disease burden. Additionally, we performed a frontier analysis of Disability-Adjusted Life Years (DALYs) due to cataract from 1990 to 2021. Finally, we used the BAPC model to project the burden of cataract by gender from 2022 to 2030.
The study revealed that the global burden of cataract remains significant. Worldwide, the Estimate Annual Percentage Change (EAPC) for cataract prevalence was 0.2117([95% CI] 0.1172-0.3063); the EAPC for cataract DALYs is -0.4798([95%CI] -0.5766--0.3828). Predominantly affecting females, individuals aged 50 and older, and those in medium-low and low SDI regions. Furthermore, the Bayesian Age-Period-Cohort (BAPC) model forecast a gradual decline in the global burden of cataract over the next nine years.
This study utilized GBD 2021 to provide an in-depth analysis of the current global disease burden of cataracts. The results showed that although the Age-Standardized Rate (ASR) of DALYs decreased, the overall cataract Number still showed an increasing trend from 1990 to 2021 and 2022-2030.
白内障是导致失明的最常见原因。手术仍然是唯一有效且被广泛接受的治疗方法；早期诊断和干预可显著预防失明。因此，了解白内障的当前流行病学状况对于制定更好的医疗政策以及有效预防白内障导致的失明至关重要。
本研究利用全球疾病负担（GBD）2021数据对1990年至2021年白内障负担进行深入分析，包括性别差异、风险因素以及社会人口指数（SDI）与疾病负担之间的关系。此外，我们对1990年至2021年白内障导致的伤残调整生命年（DALYs）进行了前沿分析。最后，我们使用BAPC模型预测2022年至2030年按性别划分的白内障负担。
研究表明，全球白内障负担仍然很重。在全球范围内，白内障患病率的估计年变化百分比（EAPC）为0.2117（[95%置信区间]0.1172 - 0.3063）；白内障DALYs的EAPC为 - 0.4798（[95%置信区间] - 0.5766 - - 0.3828）。主要影响女性、50岁及以上人群以及中低和低SDI地区的人群。此外，贝叶斯年龄 - 时期 - 队列（BAPC）模型预测未来九年内全球白内障负担将逐渐下降。
本研究利用GBD 2021对当前全球白内障疾病负担进行了深入分析。结果表明，尽管DALYs的年龄标准化率（ASR）有所下降，但从1990年至2021年以及2022 - 2030年，白内障总数总体仍呈上升趋势。
