Zamudio-Cuevas Yessica, Plata-Rodríguez Ricardo, Fernández-Torres Javier, Flores Karina Martínez, Cárdenas-Soria Víctor Hugo, Olivos-Meza Anell, Hernández-Rangel Adriana, Landa-Solís Carlos
Laboratorio de Líquido Sinovial, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Calzada México-Xochimilco #289 Col. Arenal de Guadalupe, Delegación Tlalpan, 14389, Mexico City, Mexico.
Unidad de Ingeniería de Tejidos, Terapia Celular y Medicina Regenerativa, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Calzada México-Xochimilco #289. Col. Arenal de Guadalupe, Delegación Tlalpan, 14389, Mexico City, Mexico.
Mol Biol Rep. 2022 Mar;49(3):2503-2517. doi: 10.1007/s11033-021-07051-z. Epub 2022 Jan 11.
The present review is focused on general aspects of the synovial membrane as well as specialized aspects of its cellular constituents, particularly the composition and location of synovial membrane mesenchymal stem cells (S-MSCs). S-MSC multipotency properties are currently at the center of translational medicine for the repair of multiple joint tissues, such as articular cartilage and meniscus lesions.
We reviewed the results of in vitro and in vivo research on the current clinical applications of S-MSCs, surface markers, cell culture techniques, regenerative properties, and immunomodulatory mechanisms of S-MSCs as well as the practical limitations of the last twenty-five years (1996 to 2021).
Despite the poor interest in the development of new clinical trials for the application of S-MSCs in joint tissue repair, we found evidence to support the clinical use of S-MSCs for cartilage repair. S-MSCs can be considered a valuable therapy for the treatment of repairing joint lesions.
本综述聚焦于滑膜的一般方面及其细胞成分的特殊方面，特别是滑膜间充质干细胞（S-MSCs）的组成和位置。S-MSC的多能性特性目前是用于修复多种关节组织（如关节软骨和半月板损伤）的转化医学的核心。
我们回顾了过去25年（1996年至2021年）关于S-MSCs当前临床应用、表面标志物、细胞培养技术、再生特性、免疫调节机制以及实际局限性的体外和体内研究结果。
尽管对S-MSCs在关节组织修复中的应用开展新临床试验的兴趣不大，但我们发现有证据支持S-MSCs用于软骨修复的临床应用。S-MSCs可被视为治疗关节损伤修复的一种有价值的疗法。
