State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States.
ACS Appl Bio Mater. 2021 Apr 19;4(4):3490-3498. doi: 10.1021/acsabm.1c00035. Epub 2021 Mar 8.
Current photodynamic therapy (PDT) faces several intrinsic limitations, including insufficient oxygen supply and limited penetration of external light sources. Herein, we report a nanoconjugate, which, in response to the elevated hydrogen peroxide levels associated with tumor tissues, can supplement the oxygen needed for PDT and provide local self-illumination. Consisting of a MnFeO core, a metal-organic framework shell loaded with the chemiluminescence reagent luminol, and a hyaluronic acid surface coating, the nanoconjugate is highly effective for suppressing cancer tissues in vivo via PDT in the absence of externally delivered light.
目前的光动力疗法（PDT）面临着一些内在的局限性，包括氧气供应不足和外部光源的穿透有限。在此，我们报告了一种纳米缀合物，它可以响应与肿瘤组织相关的过氧化氢水平升高，为 PDT 提供所需的氧气，并提供局部自照明。该纳米缀合物由 MnFeO 核、负载化学发光试剂鲁米诺的金属有机骨架壳和透明质酸表面涂层组成，在没有外部输送光的情况下，通过 PDT 非常有效地抑制体内的癌症组织。
