State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China.
ACS Appl Bio Mater. 2021 Apr 19;4(4):3532-3538. doi: 10.1021/acsabm.1c00060. Epub 2021 Mar 11.
The controllable intermittent and stepwise release modes were achieved in a dissipative system of supra-amphiphile. The supra-amphiphile was constructed based on complexation of cationic amphiphile (Zn@DPA-14) and biological energy currency, adenosine triphosphate (ATP). The formation of supra-amphiphile and the competing hydrolysis of ATP by enzyme drove the micelles assembled by Zn@DPA-14 away from the thermodynamic equilibrium state, leading to the cargo release from micelles during the process of micelles transformed to vesicles. Following the time-dependent evolution, the intermittent release or stepwise release modes of the loaded cargo realized through adjusting the polarity of the cargo molecules. The strategy advancing from "traditional" release modes under thermodynamic control toward the life-like controllable modes in the far-from-equilibrium state shows unique potential applications on transport vehicles and biomedical field.
超两亲分子体系中实现了可控的间歇式和分步释放模式。超两亲分子基于阳离子两亲物（Zn@DPA-14）与生物能量货币三磷酸腺苷（ATP）的复合物构建。超两亲分子的形成和酶对 ATP 的竞争水解驱动由 Zn@DPA-14 组装的胶束远离热力学平衡状态，导致在胶束转变为囊泡的过程中货物从胶束中释放。随着时间的推移，通过调整货物分子的极性，可以实现负载货物的间歇式或分步释放模式。从热力学控制下的“传统”释放模式向远离平衡状态的类似生命的可控模式的转变策略，在运输工具和生物医学领域具有独特的潜在应用。
