一种新的 - 醌甲叉环加成物：光氧化还原催化的 [6+4] 环加成反应用于合成苯并[]环戊[]氧杂[4.5]庚烯。
A new cycloaddition profile for -quinone methides: photoredox-catalyzed [6+4] cycloadditions for synthesis of benzo[]cyclopenta[]oxepines.
机构信息
Graduate School of Environment and Information Sciences, Yokohama National University, Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan.
出版信息
Chem Commun (Camb). 2022 Feb 17;58(15):2476-2479. doi: 10.1039/d1cc06332d.
PMID:35014637
Abstract
Visible-light-induced [6+4] cycloaddition reactions of -quinone methides have been developed. The reaction of -quinone methides with pentafulvenes in the presence of a thioxanthylium photoredox catalyst afforded benzo[]cyclopenta[]oxepines. The present reaction represents a promising tool for the synthesis of natural products and bioactive compounds that contain a benzoxepine structure.
摘要
可见光诱导的[6+4]环加成反应已经被开发出来。在硫杂蒽光氧化还原催化剂的存在下，-醌亚甲基与五氟乙烯反应生成苯并[环戊烯并]氧杂环戊烷。本反应为合成含有苯并[g]氧杂环戊烷结构的天然产物和生物活性化合物提供了一种很有前途的工具。
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