Peterson Andrea M., Singh Manvinder
Medical University of South Carolina
Montefiore/Einstein
There are a variety of benign and malignant indications for women that may cause a patient to seek fertility preservation counseling. Several benign conditions that may lead to early infertility include endometriosis, ovarian torsion, benign ovarian cysts, and premature ovarian insufficiency, which may be a result of genetic conditions such as Turner syndrome, Fragile X premutation, or galactosemia. In addition, there are a variety of autoimmune medical conditions such as Lupus Nephritis and hematologic conditions such as sickle cell anemia and thalassemia that may require chemotherapy, radiotherapy, a combination of both chemotherapy and radiotherapy, and in some instances, even bone marrow transplantation. These interventions for benign medical conditions may result in an early loss of fertility. Surgeries in the pelvis may also diminish a women's ovarian reserve and lead to issues with fertility.
对于女性而言，有多种良性和恶性指征可能会促使患者寻求生育力保存咨询。一些可能导致早期不孕的良性疾病包括子宫内膜异位症、卵巢扭转、良性卵巢囊肿和卵巢早衰，后者可能是由特纳综合征、脆性X前突变或半乳糖血症等遗传疾病引起的。此外，还有多种自身免疫性疾病，如狼疮性肾炎，以及血液系统疾病，如镰状细胞贫血和地中海贫血，这些疾病可能需要化疗、放疗、化疗与放疗联合使用，在某些情况下甚至需要进行骨髓移植。这些针对良性疾病的干预措施可能会导致生育力过早丧失。盆腔手术也可能会减少女性的卵巢储备并引发生育问题。
