University College London (UCL) Great Ormond Street Institute of Child Health, London, UK; UCL Cancer Institute, London, UK.
University College London (UCL) Great Ormond Street Institute of Child Health, London, UK; UCL Cancer Institute, London, UK.
Cancer Cell. 2022 Jan 10;40(1):11-13. doi: 10.1016/j.ccell.2021.12.010.
Chimeric antigen receptors (CARs) allow redirection of T cells against any surface antigen. However, CARs require optimization to achieve activity against low-density antigens. Heitzeneder et al. perform an iterative adjustment of CAR components to reach a design for targeting cerebroglycan (GPC2) that shows potent pre-clinical activity in neuroblastoma models.
嵌合抗原受体 (CARs) 可使 T 细胞重定向对抗任何表面抗原。然而，CARs 需要优化以实现对低密度抗原的活性。Heitzeneder 等人通过对 CAR 组件进行反复调整，设计出针对神经节苷脂 (GPC2) 的靶向 CAR，在神经母细胞瘤模型中显示出强大的临床前活性。
