Kunkel B, Hofmann U, Mutschler M
Medizinische Poliklinik der Universität Erlangen, F.R.G.
Z Kardiol. 1987;76 Suppl 3:159-63.
The effect of bepridil compared to verapamil on the cardiomyopathic hamster (Strain Bio 8262) was evaluated. Bepridil (10 mg/kg) was injected twice daily for 15 and 30 days. Verapamil (10 mg/kg) was injected twice daily for 30 days. Control animals were treated with NaCl. After life-day 30, large infarct-like lesions predominantly located in the central portion of the left ventricular walls were observed, while single cell necrosis occurred only in a few cases. In peripheral muscles, the necrotizing process started even before life-day 30. In the skeletal muscles, small foci of cell necrosis were the predominant type of lesion. Myocardial calcium accumulation and cell necrosis could be completely prevented by verapamil and were not influenced by bepridil. Both drugs were ineffective in the skeletal muscles. The infarct-like lesions of the myocardium demonstrate that a vascular component is involved in the pathogenesis of necrosis, in addition to the inherited disturbance of calcium metabolism. The results demonstrate that not all drugs with calcium antagonistic potencies have identical cardioprotective effects in the cardiomyopathic hamster.
评估了苄普地尔与维拉帕米对心肌病仓鼠（Bio 8262品系）的作用。苄普地尔（10毫克/千克）每日注射两次，持续15天和30天。维拉帕米（10毫克/千克）每日注射两次，持续30天。对照动物用氯化钠治疗。在第30个生命日之后，观察到主要位于左心室壁中央部分的大片梗死样病变，而单细胞坏死仅在少数情况下发生。在周围肌肉中，坏死过程甚至在第30个生命日之前就开始了。在骨骼肌中，小的细胞坏死灶是主要的病变类型。维拉帕米可完全预防心肌钙积累和细胞坏死，而苄普地尔对此无影响。两种药物对骨骼肌均无效。心肌梗死样病变表明，除了遗传性钙代谢紊乱外，血管成分也参与了坏死的发病机制。结果表明，并非所有具有钙拮抗作用的药物在心肌病仓鼠中都具有相同的心脏保护作用。
