特应性皮炎中辅助性 T 细胞 17 细胞和白细胞介素-17 的表达增加：系统评价和荟萃分析。
Increased expression of T helper 17 cells and interleukin-17 in atopic dermatitis: a systematic review and meta-analysis.
机构信息
Institute of Dermatology and Venereology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China.
Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China; Geriatric Cardiovascular Ward 3, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
出版信息
Ann Palliat Med. 2021 Dec;10(12):12801-12809. doi: 10.21037/apm-21-3590.
BACKGROUND
Atopic dermatitis (AD) is a chronic inflammatory skin disease with genetic susceptibility and recurrent attacks. Research examining the etiology of this disease has mainly focused on environmental factors and immunity, with immune disorders believed to be the main factor in the occurrence and development of AD. While some studies have demonstrated that increased proportion of T helper 17 (Th17) cells in the lesions of specific dermatitis mouse models, the expression of Th17 cells and interleukin (IL)-17 in patients with AD remains controversial.
METHODS
Related literatures were retrieved from English databases including PubMed, Embase, and Ovid-Medline. Literatures published from the establishment of the database to April 2021 were identified using the following keywords: AD, T helper cell 17 (Th17 cell), and interleukin 17 (IL-17). Review Manager5.3 software was adopted for meta-analysis.
RESULTS
A total of 8 studies, involving 1,147 subjects, related to the pathogenesis of AD were included in this meta-analysis. The analysis revealed that the expression of Th17 cells in patients with AD was higher than that in healthy patients (P<0.00001), and the serum expression of IL-17 was also elevated in patients with AD compared to healthy participants (P=0.0001).
DISCUSSION
A total of 8 publications related to the pathogenesis of AD were analyzed. The meta-analysis found that patients with AD had higher expressions of Th17 cells and IL-17 compared to healthy subjects, suggesting that AD may be related to Th17 cells and IL-17.
背景
特应性皮炎（AD）是一种具有遗传易感性和反复发作的慢性炎症性皮肤病。研究该病病因的主要集中在环境因素和免疫方面，免疫紊乱被认为是 AD 发生和发展的主要因素。虽然一些研究表明，在特定的特应性皮炎小鼠模型的病变中 Th17 细胞的比例增加，但 AD 患者 Th17 细胞和白细胞介素（IL）-17 的表达仍存在争议。
方法
从 PubMed、Embase 和 Ovid-Medline 等英文数据库中检索相关文献。使用以下关键词检索自数据库建立至 2021 年 4 月发表的文献：AD、辅助性 T 细胞 17（Th17 细胞）和白细胞介素 17（IL-17）。采用 Review Manager5.3 软件进行荟萃分析。
结果
本荟萃分析共纳入 8 项研究，涉及 1147 例 AD 发病机制相关的研究。分析结果表明，AD 患者 Th17 细胞的表达高于健康对照者（P<0.00001），AD 患者的血清 IL-17 表达也高于健康参与者（P=0.0001）。
讨论
共分析了 8 篇与 AD 发病机制相关的文献。荟萃分析发现，AD 患者 Th17 细胞和 IL-17 的表达均高于健康对照者，提示 AD 可能与 Th17 细胞和 IL-17 有关。
Zotero 插件