Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China.
Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China; Department of Geriatric Cardiovascular Ward 3, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Ann Palliat Med. 2021 Dec;10(12):12877-12885. doi: 10.21037/apm-21-3472.
This paper briefly reviews the pathological characteristics and regulatory mechanism of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome and summarizes the relationship between it and rheumatoid arthritis (RA) as a means to improve its therapeutic potential and clinical application.
RA is a systemic inflammatory disease with a high incidence rate. The early diagnosis and treatment of the disease is difficult, and the current treatment effect of most patients is not significant and accompanied by serious infection risk. Inflammation is an immune protective mechanism in the body. Inflammasome is an intracellular multi-body protein that stimulates the inflammatory response [inducing the release of pro-inflammatory cytokine interleukin (IL)-1β and IL-18] and promotes the death of thermophiles. The NLRP3 inflammatory bodies are assembled from NLRP3, apoptosis-associated speck-like protein (ASC), and pro-caspase-1. Previous studies have enriched our understanding of the activation mechanism of NLRP3 inflammasome, and animal model data suggests that it plays an important role in autoimmune diseases, including RA.
Literatures about inflammation and RA were extensively reviewed to analyze and discuss.
Especially, we focused on the role of NLRP3 inflammasome in the pathogenesis of RA and the potential of NLRP3 inflammasome or their derivatives in the treatment of RA, which enriched the treatment strategies of inflammatory diseases.
本文简要综述了 NOD 样受体家族含pyrin 结构域蛋白 3（NLRP3）炎症小体的病理特征和调控机制，并总结了其与类风湿关节炎（RA）的关系，以期提高其治疗潜力和临床应用。
RA 是一种系统性炎症性疾病，发病率较高。该疾病早期诊断和治疗困难，且多数患者的治疗效果不显著，伴有严重感染风险。炎症是机体的一种免疫保护机制，炎症小体是一种细胞内多聚体蛋白，可刺激炎症反应[诱导促炎细胞因子白细胞介素（IL）-1β和 IL-18 的释放]，促进嗜热菌死亡。NLRP3 炎症小体由 NLRP3、凋亡相关斑点样蛋白（ASC）和原胱天蛋白酶-1 组成。先前的研究丰富了我们对 NLRP3 炎症小体激活机制的认识，动物模型数据表明其在包括 RA 在内的自身免疫性疾病中发挥重要作用。
广泛查阅炎症和 RA 相关文献，并进行分析和讨论。
特别是，我们重点关注 NLRP3 炎症小体在 RA 发病机制中的作用，以及 NLRP3 炎症小体或其衍生物在 RA 治疗中的潜力，丰富了炎症性疾病的治疗策略。
