Borch K, Jansson L, Sjödahl R, Anderberg B
Department of Surgery, University Hospital, Linköping, Sweden.
Ann Chir Gynaecol. 1987;76(5):258-62.
In order to evaluate the effect of H2-receptor blockade as an adjunct to antacid treatment in non-variceal massive upper gastrointestinal haemorrhage, 106 patients were randomized to treatment with either antacid (n = 54) or cimetidine and antacid (n = 52). One patient (antacid group) died as a direct cause of bleeding. Acute surgery was carried out in 8 patients (14.8%) in the antacid group and in 4 patients (7.7%) in the cimetidine-antacid group. Continuous bleeding or re-bleeding occurred in 11 patients (20.4%) in the antacid group and in 10 patients (19.2%) in the cimetidine-antacid group. Neither these differences, nor any differences related to specific source of bleeding, were statistically significant. It is concluded that, according to the regimen applied in the present study, treatment with cimetidine does not to any significant extent influence the immediate outcome for patients with non-variceal massive upper gastrointestinal haemorrhage.
为了评估H2受体阻滞剂作为抗酸剂治疗非静脉曲张性上消化道大出血辅助药物的效果，106例患者被随机分为抗酸剂治疗组（n = 54）和西咪替丁与抗酸剂联合治疗组（n = 52）。抗酸剂治疗组有1例患者因出血直接死亡。抗酸剂治疗组有8例患者（14.8%）接受了急诊手术，西咪替丁与抗酸剂联合治疗组有4例患者（7.7%）接受了急诊手术。抗酸剂治疗组有11例患者（20.4%）出现持续出血或再出血，西咪替丁与抗酸剂联合治疗组有10例患者（19.2%）出现持续出血或再出血。这些差异以及与特定出血源相关的任何差异均无统计学意义。得出的结论是，根据本研究采用的治疗方案，西咪替丁治疗对非静脉曲张性上消化道大出血患者的近期预后没有显著影响。
