Section of Radiation Oncology, Department of Oncology, The Aga Khan University, Karachi, Pakistan.
Department of Clinical and Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore, Pakistan.
Gulf J Oncolog. 2021 May;1(36):60-66.
Abscopal effect is defined as a phenomenon where radiation delivery at one site induces shrinkage of disease at a distant site, outside the radiation field. Although it is an old concept but with recent advancements in the fields of diagnostic and therapeutic oncology, this effect has gained popularity and nowadays has become an area of interest for the researchers.With the current success of immunotherapy, there is robust and interesting data looming to evaluate potential synergistic effect of radiation coupled with immunotherapy to attain abscopal effect. Our article highlights background, mechanism and a brief literature review for abscopal response in conjunction with immunotherapy. Keywords: Abscopal Effect, Radiation, Immunotherapy, Personalized Medicine.
远隔效应是指在一个部位进行放射治疗会引起辐射野外的远处部位疾病缩小的现象。虽然这是一个古老的概念，但随着诊断和治疗肿瘤学领域的最新进展，这种效应已经变得越来越受欢迎，并且现在已经成为研究人员关注的一个领域。随着免疫疗法的当前成功，有大量有趣的数据涌现出来，以评估放射治疗与免疫疗法相结合以获得远隔效应的潜在协同作用。我们的文章强调了远隔效应的背景、机制以及与免疫疗法结合的简要文献综述。
远隔效应，放射治疗，免疫疗法，个性化医疗。
